616400-M
Tranilast
An anthranilic acid analog that acts as a potent inhibitor of VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis.
别名:
Tranilast, N-(3ʹ,4ʹ-Dimethoxycinnamoyl)anthranilic Acid
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关于此项目
经验公式（希尔记法）:
C18H17NO5
化学文摘社编号:
分子量:
327.33
UNSPSC Code:
51111800
MDL number:
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
description
Merck USA index - 14, 9570
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
pale yellow
solubility
DMSO: 200 mg/mL
storage temp.
−20°C
SMILES string
N(c2c(cccc2)C(=O)O)C(=O)\C=C\c1cc(c(cc1)OC)OC
InChI
1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+
InChI key
NZHGWWWHIYHZNX-CSKARUKUSA-N
General description
An anthranilic acid analog that acts as a potent inhibitor of VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis. Inhibits VEGF- and PMA-stimulated PKC activity in retinal capillary endothelial cells without affecting the VEGF binding or VEGF receptor phosphorylation. Also has antiallergic, anti-inflammatory, and antiproliferative properties. Induces Ca2+ mobilization in vascular smooth muscle.
Biochem/physiol Actions
Primary Target
VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis
VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis
Preparation Note
Following reconstitution, aliquot and freeze (-20°C).
Other Notes
Koyama, S., et al. 1999. Br. J. Pharmacol. 127, 537.
Isaji, M., et al. 1998. Life Sci. 63, PL71.
Isaji, M., et al. 1997. Br. J. Pharmacol. 122, 1061.
Isaji, M., et al. 1998. Life Sci. 63, PL71.
Isaji, M., et al. 1997. Br. J. Pharmacol. 122, 1061.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
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警示词
Warning
危险代码
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
怎么回事？
WGK 3
闪点 (F)
Not applicable
闪点 (°C)
Not applicable