产品名称
1-甲基-2-吡咯烷酮, suitable for chromatography
suitability
suitable for chromatography
Quality Level
SMILES string
N1(CCCC1=O)C
InChI
1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3
InChI key
SECXISVLQFMRJM-UHFFFAOYSA-N
General description
1-Methyl-2-pyrrolidone is a dipolar aprotic solvent widely used in organic chemistry for its ability to dissolve many chemicals. It is commonly used as a solvent or eluent for extracting soluble materials from soil samples using size-exclusion chromatography. NMP is a highly polar liquid and can be used for solvent extraction of polar substances from non-polar substances.
Application
- Delivery of atovaquone and proguanil across sublingual membranes, in vitro.: This study explores the sublingual delivery of the antimalarial drugs atovaquone and proguanil, using 1-Methyl-2-pyrrolidone (NMP) as a solubilizing agent to enhance drug permeability. Results demonstrate NMP′s potential to improve drug delivery efficiency through sublingual membranes (Wallace et al., 2012).
- Controlled delivery of aspirin: effect of aspirin on polymer degradation and in vitro release from PLGA based phase sensitive systems.: This research investigates the controlled release of aspirin from poly(lactic-co-glycolic acid) (PLGA) systems using NMP. The study highlights NMP′s role in modulating polymer degradation and drug release profiles, offering insights for developing controlled delivery systems (Tang and Singh, 2008).
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signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 1
flash_point_f
195.8 °F - Pensky-Martens closed cup
flash_point_c
91 °C - Pensky-Martens closed cup
法规信息
新产品
此项目有
Densities, viscosities, sound speed, and IR studies of N-methyl-2-pyrrolidone with cyclohexylamine, cyclohexanol, and cyclohexene at different temperatures
Reddy KR, et al.
Thermochimica Acta, 590, 116-126 (2014)
1-methyl-2-pyrrolidone: from exfoliating solvent to a paramagnetic ligand
Lemus-Santana AA, et al.
The Journal of Physical Chemistry A, 117(11), 2400-2407 (2013)
Examination of soil contaminated by coal-liquids by size exclusion chromatography in 1-methyl-2-pyrrolidinone solution to evaluate interference from humic and fulvic acids and extracts from peat
Morgan TJ, et al.
Journal of Chromatography A, 1095(1-2), 81-88 (2005)