General description
1-Methyl-2-pyrrolidone is a dipolar aprotic solvent widely used in organic chemistry for its ability to dissolve many chemicals. It is commonly used as a solvent or eluent for extracting soluble materials from soil samples using size-exclusion chromatography. NMP is a highly polar liquid and can be used for solvent extraction of polar substances from non-polar substances.
Application
- Delivery of atovaquone and proguanil across sublingual membranes, in vitro.: This study explores the sublingual delivery of the antimalarial drugs atovaquone and proguanil, using 1-Methyl-2-pyrrolidone (NMP) as a solubilizing agent to enhance drug permeability. Results demonstrate NMP′s potential to improve drug delivery efficiency through sublingual membranes (Wallace et al., 2012).
- Controlled delivery of aspirin: effect of aspirin on polymer degradation and in vitro release from PLGA based phase sensitive systems.: This research investigates the controlled release of aspirin from poly(lactic-co-glycolic acid) (PLGA) systems using NMP. The study highlights NMP′s role in modulating polymer degradation and drug release profiles, offering insights for developing controlled delivery systems (Tang and Singh, 2008).
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 1
flash_point_f
195.8 °F - Pensky-Martens closed cup
flash_point_c
91 °C - Pensky-Martens closed cup
法规信息
新产品
此项目有
Densities, viscosities, sound speed, and IR studies of N-methyl-2-pyrrolidone with cyclohexylamine, cyclohexanol, and cyclohexene at different temperatures
Reddy KR, et al.
Thermochimica Acta, 590, 116-126 (2014)
Examination of soil contaminated by coal-liquids by size exclusion chromatography in 1-methyl-2-pyrrolidinone solution to evaluate interference from humic and fulvic acids and extracts from peat
Morgan TJ, et al.
Journal of Chromatography A, 1095(1-2), 81-88 (2005)
1-methyl-2-pyrrolidone: from exfoliating solvent to a paramagnetic ligand
Lemus-Santana AA, et al.
The Journal of Physical Chemistry A, 117(11), 2400-2407 (2013)
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