658408
AG 490, m-CF3
A cell-permeable, reversible, substrate competitive, m-trifluoromethyl derivative of AG 490 that displays apoptotic and antiproliferative properties.
别名:
AG 490, m-CF3, NSC D722757, α-Cyano-(3,4-dihydroxy)-N-( m-trifluoromethyl)benzylcinnamide, 5H4, NSC D722757, α-Cyano-(3,4-dihydroxy)-N-(m-trifluoromethyl)benzylcinnamide, 5H4
质量水平
方案
≥98% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
yellow
溶解性
DMSO: 0.5 mg/mL
methanol: soluble
运输
ambient
储存温度
−20°C
InChI
1S/C18H13F3N2O3/c19-18(20,21)14-3-1-2-12(7-14)10-23-17(26)13(9-22)6-11-4-5-15(24)16(25)8-11/h1-8,24-25H,10H2,(H,23,26)
InChI key
CBZPIGMULPRVPO-UHFFFAOYSA-N
一般描述
A cell-permeable, reversible, substrate competitive, m-trifluoromethyl derivative of AG 490 (Cat. No. 658401) that displays apoptotic and antiproliferative properties (IC50 = 1.7 µM, 2.8 µM and 6.1 µM in 2E8, Baf/3 and Jurkat cells, respectively). Shown to inhibit IL-7-induced JAK3 tyrosine phosphorylation in 2E8 cells in vitro and significantly reduce lymph node cellularity in a murine B and T cell lymphoma model (1 mg per animal, i.p.) in vivo.
生化/生理作用
Cell permeable: yes
Primary Target
apoptotic and antiproliferative properties
apoptotic and antiproliferative properties
Product does not compete with ATP.
Reversible: yes
Target IC50: 1.7 µM, 2.8 µM and 6.1 µM for displaying apoptotic and antiproliferative properties in 2E8, Baf/3 and Jurkat cells, respectively
包装
Packaged under inert gas
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 weeks at -20°C.
其他说明
Gu, L., et al. 2005. Bioorg. Med. Chem.13, 4269.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Banglao Xu et al.
Gut microbes, 13(1), 1968258-1968258 (2021-08-26)
Clostridioides difficile infection is currently the leading cause of nosocomial antibiotic-associated diarrhea and pseudomembranous colitis worldwide. Cathelicidins, a major group of natural antimicrobial peptides, have antimicrobial and immunomodulatory activities in Clostridioides difficile infection. Here, we have shown that cytokine IL-27
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