676492
MAZ51
≥95% (HPLC), solid, VEGFR3 kinase inhibitor, Calbiochem®
别名:
VEGFR3激酶抑制剂，MAZ51, MAZ51，3-(4-二甲氨基-萘-1-基亚甲基)-1,3-二氢-吲哚-2-酮，血管内皮生长因子受体3激酶抑制剂，VEGFR酪氨酸激酶抑制剂XVI，VEGFR3激酶抑制剂I
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关于此项目
经验公式（希尔记法）:
C21H18N2O
化学文摘社编号:
分子量:
314.38
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
产品名称
VEGFR3激酶抑制剂，MAZ51, The VEGFR3 Kinase Inhibitor, MAZ51, also referenced under CAS 163655-37-6, controls the biological activity of VEGFR3 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Quality Level
SMILES string
N1c2c(cccc2)C(=Cc3c4c(c(cc3)N(C)C)cccc4)C1=O
InChI
1S/C21H18N2O/c1-23(2)20-12-11-14(15-7-3-4-9-17(15)20)13-18-16-8-5-6-10-19(16)22-21(18)24/h3-13H,1-2H3,(H,22,24)
InChI key
VFCXONOPGCDDBQ-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
red
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
2-8°C
Biochem/physiol Actions
主靶
受体酪氨酸激酶
受体酪氨酸激酶
产物与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：在低浓度（≤5 µM）下，它在PAE细胞中特异性阻断VEGF-C和VEGF-D诱导的VEGFR-3磷酸化，而不是VEGFR-2磷酸化。
Disclaimer
毒性：标准处理（A）
General description
一种细胞可渗透的3-取代吲哚-2-酮化合物，可作为VEGF受体酪氨酸激酶的可逆和ATP竞争性抑制剂。在低浓度（5 µM）下，据报道可在PAE细胞中特异性阻断VEGF-C和VEGF-D诱导的VEGFR-3磷酸化，而不是VEGFR-2磷酸化。据报道，仅在较高浓度（50 µM）时部分阻断VEGFR-2磷酸化。这种差异抑制可能有助于控制淋巴管生成依赖性的肿瘤转移，因此对癌症治疗研究具有临床意义。
Other Notes
Kirkin, V., et al. 2001.Eur. J. Biochem.268, 5530
Packaging
用惰性气体包装
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
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