676501
VEGFR Tyrosine Kinase Inhibitor V - Calbiochem
The VEGFR Tyrosine Kinase Inhibitor V controls the biological activity of VEGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
VEGFR Tyrosine Kinase Inhibitor V - Calbiochem, N-Cyclopropyl-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide, HCl, VEGF Receptor Tyrosine Kinase Inhibitor V, VEGFR2 Kinase Inhibitor XXIII, VEGFR1 Kinase Inhibitor VI, VEGFR3 Kinase Inhibitor VI
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关于此项目
经验公式（希尔记法）:
C25H22N2O4 · xHCl · yH2O
分子量:
414.45 (anhydrous free base basis)
UNSPSC Code:
12352200
Quality Level
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
beige
solubility
ethanol: 0.2 mg/mL, DMSO: 0.5 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cell-permeable, ATP-binding pocket-targeting N-cyclopropylnaphthamide compound that acts as a potent inhibitor against VEGFR1/2/3 (IC50 = 0.6 nM against VEGFR2), c-FMS, RET, Lyn, and c-KIt, while exhibiting much reduced activity against 36 other commonly studied kinases. Selectively inhibits HUVEC proliferation induced by VEGF over bFGF (IC50 = 0.91 vs. 170 nM, respectively). It is orally active in mice and rats and is shown to effectively reduce VEGF-mediated vascular permeability and angiogenesis in vivo.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Harmange, J.C., et al. 2008. J. Med. Chem.51, 1649.
Weiss, M.M., et al. 2008. J. Med. Chem.51, 1668.
Weiss, M.M., et al. 2008. J. Med. Chem.51, 1668.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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