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Merck
CN

676777

(±)-Verapamil hydrochloride

A papaverine derivative that blocks Ca2+ channels (principally the L-type) in smooth and cardiac muscle cells.

别名:

(±)-Verapamil, Hydrochloride, L-Type Calcium Channel Blocker V

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关于此项目

经验公式（希尔记法）:
C27H38N2O4 · xHCl
化学文摘社编号:
152-11-4
分子量:
454.60 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00055208

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产品名称

(±)-Verapamil, Hydrochloride, A papaverine derivative that blocks Ca2+ channels (principally the L-type) in smooth and cardiac muscle cells.

SMILES string

[Cl-].[N+H](CCCC(C(C)C)(c2cc(c(cc2)OC)OC)C#N)(CCc1cc(c(cc1)OC)OC)C

InChI

1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H

InChI key

DOQPXTMNIUCOSY-UHFFFAOYSA-N

description

Merck USA index - 14, 9950

assay

≥99% (perchloric acid titration)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

methanol: 50 mg/mL, water: 70 mg/mL, ethanol: soluble

shipped in

ambient

storage temp.

10-30°C

Quality Level

100

相关类别

General description

A derivative of papaverine that blocks Ca2+ channels (principally the L-type) in smooth and cardiac muscle cells. Vasodilator and antiarrhythmic agent. Inhibits the entry of Ca2+ through voltage-dependent Ca2+ channels in cell membranes. Blocks both activated and inactivated Ca2+ channels. An adrenergic antagonist. Induces apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro.
A papaverine derivative that blocks Ca2+ channels (principally the L-type) in smooth and cardiac muscle cells. Vasodilator and antiarrhythmic agent. Known to reduce the renal clearance of digoxin. Induces apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro.

Biochem/physiol Actions

Cell permeable: no
Product does not compete with ATP.
Reversible: no

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Lonsberry, B.B., et al. 1994. Pharmacology 49, 23.
Shchepotin, I.B., et al. 1994. Anticancer Res.14, 1027.
Janis, R., et al. 1987. Adv. Drug Res.16, 309.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

hcodes

H301,H411

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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