Name: (&#177;)-Verapamil hydrochloride
Brand: MM

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About This Item

经验公式（希尔记法）:

C₂₇H₃₈N₂O₄ · xHCl

CAS Number:

152-11-4

分子量:

454.60 (free base basis)

MDL编号:

MFCD00055208

UNSPSC代码:

12352200

NACRES:

NA.77

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Product Name

(Â±)-Verapamil, Hydrochloride, A papaverine derivative that blocks Ca²⁺ channels (principally the L-type) in smooth and cardiac muscle cells.

质量水平

100

描述

Merck USA index - 14, 9950

方案

≥99% (perchloric acid titration)

表单

solid

制造商/商品名称

Calbiochem^®

储存条件

OK to freeze

颜色

white

溶解性

methanol: 50 mg/mL
water: 70 mg/mL
ethanol: soluble

运输

ambient

储存温度

10-30°C

SMILES字符串

[Cl-].[N+H](CCCC(C(C)C)(c2cc(c(cc2)OC)OC)C#N)(CCc1cc(c(cc1)OC)OC)C

InChI

1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H

InChI key

DOQPXTMNIUCOSY-UHFFFAOYSA-N

一般描述

A derivative of papaverine that blocks Ca²⁺ channels (principally the L-type) in smooth and cardiac muscle cells. Vasodilator and antiarrhythmic agent. Inhibits the entry of Ca²⁺ through voltage-dependent Ca²⁺ channels in cell membranes. Blocks both activated and inactivated Ca²⁺ channels. An adrenergic antagonist. Induces apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro.

A papaverine derivative that blocks Ca²⁺ channels (principally the L-type) in smooth and cardiac muscle cells. Vasodilator and antiarrhythmic agent. Known to reduce the renal clearance of digoxin. Induces apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro.

生化/生理作用

Cell permeable: no

Product does not compete with ATP.

Reversible: no

其他说明

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Lonsberry, B.B., et al. 1994. Pharmacology 49, 23.
Shchepotin, I.B., et al. 1994. Anticancer Res.14, 1027.
Janis, R., et al. 1987. Adv. Drug Res.16, 309.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Toxic (F)

象形图

GHS06,GHS09

警示用语：

Danger

危险声明

H301,H411

预防措施声明

P264 - P273 - P301 + P310 - P391 - P405 - P501

危险分类

Acute Tox. 3 Oral - Aquatic Chronic 2

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)