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681635

W-12, Hydrochloride

Name: W-12, Hydrochloride
Brand: MM

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 300 µM) and Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 260 µM).

别名:

W-12, Hydrochloride, N-(4-Aminobutyl)-2-naphthalenesulfonamide, HCl

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关于此项目

经验公式（希尔记法）:

C₁₄H₁₈N₂O₂S · xHCl

化学文摘社编号:

89108-46-3

分子量:

278.37 (free base basis)

UNSPSC Code:

12352200

MDL number:

MFCD00058052

Assay:

≥97% (TLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, desiccated (hygroscopic), protect from light

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属性

Quality Level

100

assay

≥97% (TLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

white

solubility

water: 1 mg/mL, ethanol: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C14H18N2O2S.ClH/c15-9-3-4-10-16-19(17,18)14-8-7-12-5-1-2-6-13(12)11-14;/h1-2,5-8,11,16H,3-4,9-10,15H2;1H

InChI key

WYFVKUWCEVMLOL-UHFFFAOYSA-N

说明

General description

A cell-permeable and reversible calmodulin antagonist that inhibits Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 260 µM) and myosin light chain kinase (IC₅₀ = 300 µM).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Myosin light chain kinase (Mlck)

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 300 µM and 260 µM against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase, respectively.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Tanaka, T., et al. 1983. Pharmacol.26, 249.
Asano, M., et al. 1982. J. Pharmacol. Exp. Ther.220, 191.
Hidaka, H. 1981. Prot. Nuc. Acid Enz.26, 977.
Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem.255, 11078.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c