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About This Item
经验公式（希尔记法）:
C14H18N2O2S · xHCl
CAS Number:
分子量:
278.37 (free base basis)
MDL编号:
UNSPSC代码:
12352200
质量水平
方案
≥97% (TLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
颜色
white
溶解性
water: 1 mg/mL
ethanol: 5 mg/mL
运输
ambient
储存温度
−20°C
InChI
1S/C14H18N2O2S.ClH/c15-9-3-4-10-16-19(17,18)14-8-7-12-5-1-2-6-13(12)11-14;/h1-2,5-8,11,16H,3-4,9-10,15H2;1H
InChI key
WYFVKUWCEVMLOL-UHFFFAOYSA-N
一般描述
A cell-permeable and reversible calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 260 µM) and myosin light chain kinase (IC50 = 300 µM).
生化/生理作用
Cell permeable: yes
Primary Target
Myosin light chain kinase (Mlck)
Myosin light chain kinase (Mlck)
Product does not compete with ATP.
Reversible: yes
Target IC50: 300 µM and 260 µM against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase, respectively.
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Tanaka, T., et al. 1983. Pharmacol.26, 249.
Asano, M., et al. 1982. J. Pharmacol. Exp. Ther.220, 191.
Hidaka, H. 1981. Prot. Nuc. Acid Enz.26, 977.
Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem.255, 11078.
Asano, M., et al. 1982. J. Pharmacol. Exp. Ther.220, 191.
Hidaka, H. 1981. Prot. Nuc. Acid Enz.26, 977.
Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem.255, 11078.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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