assay
≥98% (HPLC)
form
crystalline solid
color
white
solubility
DMSO: 50 mg/mL
General description
A potent peroxisome proliferator. A hepatocarcinogen and tumor promoter. Also acts as a potent anti-hypercholesterolemic agent.
One of the most potent peroxisome proliferator-activated receptor α (PPARα) ligands. Inhibits TNF-α induced expression of VCAM-1 in endothelial cells. A hepatocarcinogen and tumor promoter. Also acts as a potent anti-hypercholesterolemic agent.
Biochem/physiol Actions
Peroxisome proliferator-activated receptor 7alpha; (PPARα) ligands
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
N Marx et al.
Circulation, 99(24), 3125-3131 (1999-06-22)
Adhesion molecule expression on the endothelial cell (EC) surface is critical for leukocyte recruitment to atherosclerotic lesions. Better understanding of transcriptional regulation of adhesion molecules in ECs may provide important insight into plaque formation. Peroxisome proliferator-activated receptor-alpha (PPARalpha), a member
K Murakami et al.
Biochemical and biophysical research communications, 260(3), 609-613 (1999-07-15)
The alpha isoform of peroxisome proliferators-activated receptor (PPAR) is activated by fatty acids, their metabolites, and the fibrate class of lipid-lowering agents. To test the ability of these activators to directly bind the ligand-binding domain of human PPARalpha, we performed
C Dreyer et al.
Cell, 68(5), 879-887 (1992-03-06)
Three novel members of the Xenopus nuclear hormone receptor superfamily have been cloned. They are related to each other and similar to the group of receptors that includes those for thyroid hormones, retinoids, and vitamin D3. Their transcriptional activity is
J D Tugwood et al.
Annals of the New York Academy of Sciences, 804, 252-265 (1996-12-27)
We have been attempting to elucidate the molecular mechanisms through which peroxisome proliferators exert their pleiotropic effects, with particular emphasis on understanding why humans appear unresponsive to these compounds. There is a wealth of data to implicate the peroxisome proliferator-activated
H Keller et al.
Trends in endocrinology and metabolism: TEM, 4(9), 291-296 (1993-11-01)
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily like the steroid, thyroid, or retinoid hormone receptors, which are ligand-activated transcription factors regulating gene expression. PPARs mediate the induction of the enzymes of the peroxisomal and microsomal
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