Xestospongin C, Xestospongia sp.

A macrocyclic bis-1-oxaquinolizidine natural product isolated from a marine sponge. A very potent, reversible and membrane-permeable blocker of IP₃-mediated Ca²⁺ release (IC₅₀ = 358 nM) that does not interact with the IP₃-binding site. Displays high selectivity over the skeletal isoform of the ryanodine receptor type 1 (Ry₁R). Also blocks bradykinin- and carbamylcholine-induced Ca²⁺ efflux from the ER stores in a reversible manner.

An oxaquinolizidine alkaloid isolated from a marine sponge. A very potent, reversible, and membrane-permeable blocker of IP₃-mediated Ca²⁺ release (IC₅₀ = 358 nM) that does not interact with the IP₃-binding site. Displays high selectivity over the skeletal isoform of the ryanodine receptor type 1 (RyR-1). Also blocks bradykinin- and carbamylcholine-induced Ca²⁺ efflux from the endoplasmic reticulum stores in a reversible manner.

Primary Target
IP3-mediated Ca2+ release

Target IC₅₀: 358 nM in blocking IP3-mediated Ca2+ release

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonication may be required to achieve complete solubilization.

Oka, T., et al. 2002. Br. J. Pharmacol.135, 1959.
Gafni, J., et al. 1997. Neuron 19, 723.
Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111.
Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876.
Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505.
Nakagawa, M., et al. 1984. Tetrahedron Lett.25, 3227.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Harmful (C)