MSNT

This versatile reagent was originally used as a coupling reagent in phosphotriester oligonucleotide synthesis [1-3]. In recent years, it has been increasingly used for the esterification of Fmoc-amino acids onto solid phase synthesis supports [4-12]. It has proved particularly effective in difficult cases involving unreactive linkers [8, 9] or enantiomerization prone amino acids [7]. In an investigation [6] into ester formation, in which the alcohol or carboxylic acid component was immobilized on a solid support, MSNT was found to give the best results of all the reagents tested (DCC, DCC/HOBt, DCC/DMAP, Ph₃P/DEAD).

The product number for this product was previously 01-62-0021.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 95.0 % (a/a)

Replaces: 01-62-0021

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany