产品名称
MILLIPLEX® AAV Serotyping Panel,
Quality Level
description
Simultaneously analyze up to 6 antibodies in a bead-based assay using Luminex® technology, in human serum and plasma
species reactivity
human
manufacturer/tradename
Milliplex®
technique(s)
multiplexing: suitable
input
plasma
serum
detection method
fluorometric (Luminex® xMAP® technology)
shipped in
wet ice
storage temp.
2-8°C
General description
Adeno-associated virus (AAV) is recognized as a preferred vector for gene therapy due to its infectivity, versatility, and favorable safety profile. The various AAV serotypes exhibit distinct tissue specificities, transduction efficiencies, and immunogenicity, allowing for tailored approaches to gene therapy. While AAV generally has low immunogenicity, exposure to these viruses is common which leads to a high rate of seroprevalence in the general population. Pre-existing antibodies against AAV can challenge a gene therapy’s safety and efficacy making it essential to assess seroprevalence and immunogenicity in descriptive preclinical testing.
Application
MILLIPLEX® Qualified assays undergo rigourous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 6 anti-AAV antibodies in human serum and plasma.
Analytes included: anti-AAV1, anti-AAV2, anti-AAV5, anti-AAV6, anti-AAV8, anti-AAV9
Assay Characteristics: Refer to kit protocol for assay cross-reactivity and sensitivity.
Analytes included: anti-AAV1, anti-AAV2, anti-AAV5, anti-AAV6, anti-AAV8, anti-AAV9
Assay Characteristics: Refer to kit protocol for assay cross-reactivity and sensitivity.
Features and Benefits
- Pioneering Technology: This first of its kind assay provides researchers provides a powerful tool to study immune responses to various AAV serotypes.
- Multiplex Detection: Simultaneously detects antibodies to multiple AAV serotypes (AAV1, AAV2, AAV5, AAV6, AAV8, & AAV9) plus 4 assay control beads.
- Complete Solution: Includes all necessary reagents and an intuitive protocol thus streamlining the workflow and reducing the need for multiple assays.
- Demonstrated Precision and Specificity: Ensures high reliability with <10% intra-assay CV and <15% inter-assay CV, while specificity testing with serotype-specific control antibodies confirmed negligible cross-reactivity to non-specific antigens in most cases.
Preparation Note
Recommended storage for kit components is 2-8˚C.
Legal Information
Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1
存储类别
10 - Combustible liquids
wgk
WGK 3
法规信息
新产品
此项目有
相关内容
MILLIPLEX® multiplex assays provide a comprehensive catalog of biomarkers, offering unique analytes not available from other Luminex® assay suppliers.
Cancer biomarker detection through MILLIPLEX® multiplex cancer assays can accelerate studies of tumorigenic processes helping advance cancer research.