MAB11041
抗5-羟色胺受体1A抗体，克隆19A9.2
clone 19A9.2, from mouse
别名:
5-hydroxytryptamine (serotonin) receptor 1A, 5-hydroxytryptamine receptor 1A, guanine nucleotide-binding regulatory protein-coupled receptor, Serotonin receptor 1A, G protein coupled receptor, 5-HT1a receptor
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
19A9.2, monoclonal
Application:
IHC, WB
Citations:
4
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
19A9.2, monoclonal
species reactivity
human, rat
technique(s)
immunohistochemistry: suitable, western blot: suitable
isotype
IgMκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HTR1A(3350)
rat ... Htr1A(24473)
General description
5-羟色胺受体1A，也称为5-羟色胺受体1A，是G蛋白偶联受体家族的成员。已发现5-羟色胺受体1A在隔膜和海马体中高度表达。5-羟色胺受体1A似乎通过N-通道和L-通道对Ca2+通道具有抑制性效应。受体使用N-通道激活电压敏感的减慢，并使用L-通道激活稳态抑制。
观测值〜40 kDa。 计算的分子量为46 kDa
Immunogen
对应于大鼠5-羟色胺受体1A的KLH结合的线性肽。
Application
免疫组化分析：一个先前批次以1：400的稀释度在正常人脑组织中检测到5-羟色胺受体1A。
抗5-羟色胺受体1A抗体，克隆19A9.2是一种抗5-羟色胺受体1A的抗体，用于WB，IH。
研究子类别
信号神经科学
信号神经科学
研究类别
神经科学
神经科学
Physical form
形式：纯化
纯化的小鼠单克隆IgMκ，溶于含0.05％叠氮化钠的PBS缓冲液中
Preparation Note
自收到之日起，在 2-8°C 条件下可稳定保存1年
Analysis Note
对照
小鼠脑组织裂解物
小鼠脑组织裂解物
通过蛋白质印迹在大鼠脑组织裂解物中进行了评估。
蛋白质印迹分析：0.5 µg/mL 的该抗体在 10 µg 大鼠脑组织裂解物中检测到突5-羟色胺受体1A。
蛋白质印迹分析：0.5 µg/mL 的该抗体在 10 µg 大鼠脑组织裂解物中检测到突5-羟色胺受体1A。
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Emily J Reedich et al.
The Journal of physiology, 601(19), 4271-4289 (2023-08-16)
Cerebral palsy (CP) is caused by a variety of factors that damage the developing central nervous system. Impaired motor control, including muscle stiffness and spasticity, is the hallmark of spastic CP. Rabbits that experience hypoxic-ischaemic (HI) injury in utero (at
Laura García-Durán et al.
International journal of molecular sciences, 22(19) (2021-10-14)
Selective 5-HT reuptake inhibitor antidepressants (SSRIs) are the first choice in major depressive disorder (MDD), but 50% of affected patients do not show improvement. Galanin(1-15) [GAL(1-15)] enhanced Fluoxetine antidepressant-like effects in an animal model of depression, the olfactory bulbectomy (OBX);
Shaoyuan Li et al.
Molecular pain, 14, 1744806918787368-1744806918787368 (2018-06-21)
Painful neuropathy is a frequent comorbidity in diabetes. Zucker diabetic fatty (fa/fa) rats develop type 2 diabetes spontaneously with aging and show nociceptive hypersensitivity at the age of 13 weeks. In preclinical and clinical studies, the treatment of diabetic neuropathy
Elenia Cinelli et al.
The European journal of neuroscience, 52(8), 3903-3917 (2020-05-08)
In mammals, 5-HTexcitatory respiratory effects imply 5-HT1A receptor-mediated disinhibition of pre-Bötzinger complex neurons. In the lamprey, 5-HT1A receptors are involved in the neural control of locomotion, but their role in the respiratory regulation, particularly at the level of the putative
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