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Merck
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MAB1407P

抗巨噬细胞/粒细胞抗体，克隆OX-41

clone OX-41, Chemicon®, from mouse

别名:

CD172 antigen-like family member A, CD172a antigen, Inhibitory receptor SHPS-1, Macrophage fusion receptor, MyD-1 antigen, SHP substrate 1, SHP substrate-1, Signal-regulatory protein alpha-1, signal-regulatory protein alpha

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
OX-41, monoclonal
Application:
FACS, ICC, IHC (p), WB
Citations:
7

主要文件

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biological source

mouse

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

OX-41, monoclonal

purified by

affinity chromatography

species reactivity

mouse, human, rat

manufacturer/tradename

Chemicon®

technique(s)

flow cytometry: suitable, immunocytochemistry: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, western blot: suitable

isotype

IgG2a

NCBI accession no.

NP_001035111

UniProt accession no.

P78324

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... SIRPA(140885)

相关类别

General description

56 kDa
巨噬细胞和粒细胞表达信号调节蛋白（SIRP）， SIRP是一种跨膜糖蛋白，参与细胞粘附、生长因子或胰岛素诱导的酪氨酸激酶受体信号转导的下调。它们是CD47的免疫球蛋白样细胞表面受体。CD47结合对吞噬、肥大细胞活化和树突状细胞活化有负向调控作用，可阻止未成熟树突状细胞成熟，抑制成熟树突状细胞产生细胞因子。

Immunogen

大鼠腹腔巨噬细胞。

Application

免疫组化：
冷冻切片和福尔马林固定，石蜡包埋组织切片（需要胰蛋白酶或蛋白酶预处理）。

蛋白质印迹：
该抗体的一个先前批次被用于蛋白质印迹。

流式细胞术：
使用先前批次的1:100-1:200稀释液。（使用10 μL工作稀释液，细胞数量10^6，体积100 μL）。

最佳工作稀释度必须由最终用户进行确定。
研究子类别
炎症 & 自身免疫机制
研究类别
炎症 & 免疫学
该抗巨噬细胞/粒细胞抗体，克隆OX-41，经验证可用于FC、IC、IH、IH(P)、WB中巨噬细胞/粒细胞的检测。

Biochem/physiol Actions

MAB1407P识别髓细胞和神经元选择性表达的大鼠SIRP（信号调节蛋白）。该单克隆结合在SIRP上与ED9不同的表位上。它不阻断CD172a和CD47的相互作用。
标记大多数巨噬细胞，包括常驻腹膜、肺泡和活化的巨噬细胞。对其他巨噬细胞的识别仅限于偶尔的Kupffer细胞。此外它能标记粒细胞和树突状细胞群。它还广泛地标记大脑。
预期与大鼠和小鼠发生交叉反应。

Physical form

免疫亲和纯化
纯化的小鼠单克隆IgG2a，溶于含0.09%叠氮化钠的缓冲液中。

Preparation Note

自收到之日起以未稀释的等分试样形式，在2-8°C可稳定保存6个月。

Analysis Note

对照
巨噬细胞、单核细胞、淋巴器官。
通过免疫细胞化学对巨噬细胞/粒细胞进行常规评估。

免疫细胞化学分析：
使用抗巨噬细胞/粒细胞小鼠单克隆抗体对巨噬细胞/粒细胞进行共聚焦荧光分析。

Other Notes

替代：MAB1407
浓度：请参考批次特异性浓缩物的检验报告。

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Anthony Tam et al.
Respiratory research, 21(1), 46-46 (2020-02-09)
Female smokers have increased risk for chronic obstructive pulmonary disease (COPD) compared with male smokers who have a similar history of cigarette smoke exposure. Tertiary lymphoid follicles are often found in the lungs of patients with severe COPD but sex-related
Xin-Mei Zhang et al.
Molecular vision, 16, 2867-2872 (2011-01-05)
To establish a robust method to isolate primary retinal ganglion cells (RGCs) from human fetal retina for long-term culture while maintaining neuronal morphology and marker protein expression. A total of six human retinas were obtained from aborted fetuses at 10
Mao Nakayama et al.
Molecular vision, 17, 1784-1793 (2011-07-15)
This study was conducted to investigate the effect of flavonoids, a major family of antioxidants contained in foods, on retinal ganglion cell (RGC) death induced by hypoxia, excessive glutamate levels, and oxidative stress. Moreover, to assess the structure-activity relationships of
Jun Nagai et al.
Scientific reports, 5, 8269-8269 (2015-02-06)
Axonal outgrowth inhibitors and scar formation are two major obstacles to central nervous system (CNS) repair. No target molecule that regulates both axonal growth and scarring has been identified. Here we identified collapsin response mediator protein 4 (CRMP4), a common
Xin Ding et al.
Nature communications, 12(1), 2030-2030 (2021-04-03)
Microglia play a key role in regulating synaptic remodeling in the central nervous system. Activation of classical complement pathway promotes microglia-mediated synaptic pruning during development and disease. CD47 protects synapses from excessive pruning during development, implicating microglial SIRPα, a CD47

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