MAB2624
抗内皮粘蛋白抗体，克隆V.5C7
clone V.5C7, from rat
别名:
Endomucin-2, Gastric cancer antigen Ga34, Mucin-14, MUC-14, Endomucin-1/2
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
V.5C7, monoclonal
Application:
FACS, IHC, IP, WB
Citations:
18
biological source
rat
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
V.5C7, monoclonal
species reactivity
mouse
technique(s)
flow cytometry: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Emcn(59308)
General description
内啡肽是一种内皮唾液分泌蛋白，属于一类糖蛋白，特征是高水平的o -糖解离和丰富的唾液酸。它可以抑制黏附聚集并阻碍细胞外基质和细胞的相互作用。在肾、心、脑、肝、肺、脾和胸腺中表达最多。内啡肽只存在于内皮细胞中。
观察值为~ 75kDa
Immunogen
小鼠内皮粘蛋白细胞
Application
免疫沉淀分析： 一个先前批次已被独立实验室用于bEND细胞裂解物的IP（Morgan, 1999）。
免疫组织化学分析： 一个先前批次已被独立实验室用于小鼠舌头、心脏、子宫、大脑和小肠冷冻和石蜡包埋组织切片的免疫组织化学染色（Morgan, 1999）。
流式细胞术分析： 一个先前批次已被独立实验室用于转染COS-7细胞的FC（Morgan, 1999）。
免疫组织化学分析： 一个先前批次已被独立实验室用于小鼠舌头、心脏、子宫、大脑和小肠冷冻和石蜡包埋组织切片的免疫组织化学染色（Morgan, 1999）。
流式细胞术分析： 一个先前批次已被独立实验室用于转染COS-7细胞的FC（Morgan, 1999）。
抗内皮粘蛋白抗体，克隆V.5C7可检测内皮粘蛋白水平，已发布，经验证可用于WB、IP、IH、FC。
研究子类别
细胞器&细胞标志物
粘附（CAM）
细胞器&细胞标志物
粘附（CAM）
Physical form
形式：纯化
Analysis Note
对照
bEND3细胞裂解液
bEND3细胞裂解液
已通过蛋白质印迹在小鼠内皮瘤细胞系中进行了评估。
蛋白质印迹分析： 0.0025 µg/mL该抗体可在10 µg的bEND3细胞裂解液中检测到内皮粘蛋白。
蛋白质印迹分析： 0.0025 µg/mL该抗体可在10 µg的bEND3细胞裂解液中检测到内皮粘蛋白。
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Kristina Y Aguilera et al.
Bio-protocol, 4(19) (2014-10-05)
Therapy-induced hypoxia drives changes in the tumor microenvironment that contribute to the poor response to therapy. Hypoxia is capable of driving the expression and/or activation of specific signaling cascades (e.g., c-Met, Axl, CTGF), the recruitment of tumor promoting immune cells
Meghan Grojean et al.
Journal of cellular and molecular medicine, 25(11), 4950-4961 (2021-05-04)
Elevated expression of multiple growth factors and receptors including c-Met and VEGFR has been reported in gastric adenocarcinoma (GAC) and thus provides a potentially useful therapeutic target. The therapeutic efficacy of foretinib, a c-Met/VEGFR2 inhibitor, was determined in combination with
Kate Crawford et al.
Cancer biology & therapy, 22(10-12), 619-629 (2021-12-10)
Standard chemotherapy regimens for gastric adenocarcinoma (GAC) have limited efficacy and considerable toxicity profiles. Nab-paclitaxel has shown promising antitumor benefits in previous GAC preclinical studies. Dovitinib inhibits members of the receptor tyrosine kinase family including FGFR, VEGFR and PDGFR, and
Enhancing gastric cancer conventional chemotherapy effects by triple angiokinase inhibitor nintedanib in preclinical models.
Awasthi, et al.
Frontiers in Oncology, 13, 1145999-1145999 (2023)
Priya Balasubramanian et al.
Nutrients, 16(7) (2024-04-13)
High-fat diets (HFDs) have pervaded modern dietary habits, characterized by their excessive saturated fat content and low nutritional value. Epidemiological studies have compellingly linked HFD consumption to obesity and the development of type 2 diabetes mellitus. Moreover, the synergistic interplay
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