AB10533
抗-LMX-1抗体
serum, from rabbit
别名:
LIM homeobox transcription factor 1, alpha, LIM/homeobox protein 1.1, LIM/homeobox protein LMX1A
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
69
biological source
rabbit
conjugate
unconjugated
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, hamster
species reactivity (predicted by homology)
hamster (based on 100% sequence homology)
technique(s)
western blot: suitable
isotype
IgG
GenBank accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
hamster ... Lmx1A(101839559)
mouse ... Lmx1A(110648)
rat ... Lmx1A(289201)
General description
LIM同源盒转录因子1-α（UniProt：Q04650；也称LIM/同源框蛋白LMX1A、LIM/同源框蛋白1、LMX-1）由仓鼠的LMX1（也称LMX1）基因（基因ID：101839559）编码。LMX-1是一种转录因子，属于LIM-同源域（LIM-HD）转录因子家族。它是在腹中脑内诱导的，作为对早期信号的反应。LMX-1是顶板发育和CNS背细胞日期规范和椎骨发育的必要组成部分。它在顶板中表达，顶板是在背侧中枢神经系统中发现的组织基因座，其功能是通过分泌信号分子（例如WNT和BMP）来调节相邻神经元的分化和规范。最近的研究表明，LMX-1具有刺激中脑多巴胺神经元（mesDA）产生的高潜能，用于治疗治疗帕金森病，这种疾病的特征是黑质致密部（SN）内mesDA神经元变性进展导致多巴胺能神经传递下降。
目标分子量：观察值为~38 kDa。计算分子量为42.8 kDa。在一些裂解液中可能会观察到未表征的条带。
Immunogen
GST标记的重组片段，对应于仓鼠LMX-1 C端区域的80个氨基酸。
表位：C端
Application
Anti-LMX-1（货号AB10533）是一种兔多克隆抗体，可检测小鼠LMX-1，经过测试可用于蛋白质印迹法。
测试应用 蛋白印迹分析：该抗体稀释1:1,000时，可检测带有GST、His和TEV标签的仓鼠LMX-1蛋白。 注意：实际最佳工作稀释度必须由最终用户确定，因为样本和实验条件可能会因最终用户而有所不同。
研究子类别
神经 & 胶质标记
神经 & 胶质标记
Biochem/physiol Actions
Anti-LMX-1是一种检测LMX-1的兔多克隆抗体。它靶向表位位于距C端一半的80个氨基酸之内。
Physical form
兔多克隆抗体，溶于含0.05％叠氮化钠的血清中。
未纯化
Preparation Note
储存于-10°C至-25°C。 处理建议：收货后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。分装到微量离心管中，并储存于-20°C。避免反复冻融循环，否则可能损坏IgG并影响产品性能。
Analysis Note
对照
小鼠睾丸组织裂解液
小鼠睾丸组织裂解液
通过蛋白质印迹法对小鼠睾丸组织裂解液进行了评估。 蛋白印迹分析：该抗体的1:1000稀释液可在人脑组织裂解液中检测到LMX-1。
Other Notes
Legal Information
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Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
WGK 1
Yanhan Huang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(23), 5429-5440 (2018-05-18)
LIM-domain containing transcription factors (LIM-TFs) are conserved factors important for embryogenesis. The specificity of these factors in transcriptional regulation is conferred by the complexes that they form with other proteins such as LIM-domain-binding (Ldb) proteins and LIM-domain only (LMO) proteins.
Satoshi Okawa et al.
Nature communications, 9(1), 2595-2595 (2018-07-04)
Single-cell RNA sequencing allows defining molecularly distinct cell subpopulations. However, the identification of specific sets of transcription factors (TFs) that define the identity of these subpopulations remains a challenge. Here we propose that subpopulation identity emerges from the synergistic activity
Parthiv Haldipur et al.
eLife, 6 (2017-01-17)
FOXC1 loss contributes to Dandy-Walker malformation (DWM), a common human cerebellar malformation. Previously, we found that complete Foxc1 loss leads to aberrations in proliferation, neuronal differentiation and migration in the embryonic mouse cerebellum (Haldipur et al., 2014). We now demonstrate
Charles Y Lin et al.
Nature, 530(7588), 57-62 (2016-01-28)
Medulloblastoma is a highly malignant paediatric brain tumour, often inflicting devastating consequences on the developing child. Genomic studies have revealed four distinct molecular subgroups with divergent biology and clinical behaviour. An understanding of the regulatory circuitry governing the transcriptional landscapes
M Diana Neely et al.
Toxicological sciences : an official journal of the Society of Toxicology, 159(2), 366-379 (2017-10-01)
Parkinson's disease (PD) is the result of complex interactions between genetic and environmental factors. Two chemically distinct environmental stressors relevant to PD are the metal manganese and the pesticide rotenone. Both are thought to exert neurotoxicity at least in part
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