biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
rat, mouse, human
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
General description
大约55 kDa
烟碱型乙酰胆碱受体,也称nAChR,属于配体门控离子通道蛋白家族,在神经系统中广泛表达。 nAChR包含5个亚基(两个α 和三个β)。 亚基 α4和 β2(α4β2)是哺乳动物大脑中的主要受体,与烟碱的正向强化作用有关。 对于nAChR β2和β4的相对分布我们理解不足,因为周围神经系统中介导突触传递的亚基结构是未知的。
Immunogen
该抗体是以选自烟碱型乙酰胆碱受体β2残基的KLH偶联线性肽免疫的兔产生的。
Application
使用经验证可用于WB的该抗烟碱型乙酰胆碱受体β2 抗体检测烟碱型乙酰胆碱受体β2 。
Biochem/physiol Actions
该抗体可识别烟碱型乙酰胆碱受体β2。
Analysis Note
已通过蛋白质印迹在大鼠e16脑裂解物中进行了评估。
蛋白质印迹分析:: 该批次的1:20,000稀释液在10 µg大鼠e16 脑裂解物中检测到烟碱型乙酰胆碱受体β2 。
蛋白质印迹分析:: 该批次的1:20,000稀释液在10 µg大鼠e16 脑裂解物中检测到烟碱型乙酰胆碱受体β2 。
Other Notes
浓度:请参考批次特异性浓缩物的检验报告。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Sarah Y Sottile et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(47), 11377-11389 (2017-10-25)
Acetylcholine (ACh) is a potent neuromodulator capable of modifying patterns of acoustic information flow. In auditory cortex, cholinergic systems have been shown to increase salience/gain while suppressing extraneous information. However, the mechanism by which cholinergic circuits shape signal processing in
Charles C Lee et al.
Neuroreport, 26(12), 688-694 (2015-07-15)
The thalamocortical pathways form highly topographic connections from the primary sensory thalamic nuclei to the primary cortical areas. The synaptic properties of these thalamocortical connections are modifiable by activation from various neuromodulators, such as acetylcholine. Cholinergic activation can alter functional
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