AB2232
Anti-Atrial Natriuretic Polypetide Antibody, alpha
from rabbit
别名:
Atrial natriuretic peptide, natriuretic peptide precursor A, natriuretic peptide precursor A variant 2
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
western blot
Species reactivity:
rat, mouse, human
Citations:
3
Technique(s):
western blot: suitable
Uniprot accession no.:
产品名称
Anti-Atrial Natriuretic Polypetide Antibody, alpha, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rat, mouse, human
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... NPPA(4878)
Analysis Note
Control
Rat Heart
Rat Heart
Routinely evaluated by western blot
Application
Non-Lot Specific Tested Application 1:
Immunohistochemistry:
1:50-1:500 on paraffin embedded tissue.
Optimum dilutions need to be determined by the end user.
Immunohistochemistry:
1:50-1:500 on paraffin embedded tissue.
Optimum dilutions need to be determined by the end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
Neurotransmitters & Receptors
This Anti-Atrial Natriuretic Polypetide Antibody, alpha is validated for use in WB for the detection of Atrial Natriuretic Polypetide.
Biochem/physiol Actions
Cat. # AB2232 recognizes ANP, alpha
May react with dog, cat and cow based on sequence homology.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Atrial natriuretic polypeptide, alpha (ANP), atrial natriuretic factor (ANF), or atriopeptin, is a protein (polypeptide) hormone secreted by heart muscle cells. It is involved in the homeostatic control of body water, sodium, potassium and fat (adiposity). It is released by muscle cells in the upper chambers (atria) of the heart (atrial myocytes), in response to high blood pressure. ANP acts to reduce the water, sodium and adipose loads on the circulatory system, thereby reducing blood pressure. ANP binds to a specific set of receptors - ANP receptors. Receptor-agonist binding causes a reduction in blood volume and therefore a reduction in cardiac output and systemic blood pressure. Lipolysis is increased and renal sodium reabsorption is decreased. The overall effect of ANP on the body is to counter increases in blood pressure and volume caused by the renin-angiotensin system (1).
~17 kDa
Immunogen
Synthetic Linear Peptide
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Format: Purified
Purified
Purified in 0.1M Tris-Glycine (pH7.4) 15mM NaCl with 0.05% NaN3
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Handling Recommendations: Prior to removing the cap, gently centrifuge the vial and gently mix the solution.
Handling Recommendations: Prior to removing the cap, gently centrifuge the vial and gently mix the solution.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Nirmal Verma et al.
Scientific reports, 11(1), 20926-20926 (2021-10-24)
Population-based studies identified an association between a prior pregnancy complicated by gestational diabetes mellitus (GDM) and cardiac hypertrophy and dysfunction later in life. It is however unclear whether GDM initiates this phenotype and what are the underlying mechanisms. We addressed
Jasenka Kraljevic et al.
Cardiovascular research, 99(1), 55-64 (2013-04-05)
Following a large myocardial infarction (MI), remaining viable muscle often undergoes pathological remodelling and progresses towards chronic heart failure. Mitochondria may also be affected by this process and, due to their functional importance, likely contribute to the progression of the
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