AB3096
抗促食欲素抗体，前体
Chemicon®, from rabbit
别名:
Anti-NRCLP1, Anti-OX, Anti-PPOX
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IHC, WB
Citations:
18
biological source
rabbit
conjugate
unconjugated
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, human, rat
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable, immunohistochemistry: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PPOX(5498)
Immunogen
17肽（称为PPOXA11-A）定位在小鼠前体食欲素的C末端附近。
Application
抗食欲素抗体，前体是用于ELISA，IH&WB的针对食欲素的抗体。
研究子类别
代谢的CNS控制
昼夜节律性&睡眠
代谢的CNS控制
昼夜节律性&睡眠
研究类别
神经科学
神经科学
蛋白质印迹：使用化学发光技术为1-10μg/mL
ELISA：1：10,000 - 100,000
免疫组化：2-20 μg/mL。
最佳工作稀释度必须由最终用户进行确定。
ELISA：1：10,000 - 100,000
免疫组化：2-20 μg/mL。
最佳工作稀释度必须由最终用户进行确定。
Biochem/physiol Actions
小鼠前体食欲素。 最近已经报告了几种与进食行为有关的肽。 食欲素（食欲素-A和食欲素-B）是在下丘脑中选择性表达的下丘脑神经肽家族（Sakurai et al.1998）。 食欲素-A和食欲素-B通过蛋白水解裂解衍生自相同的前体（前体-食欲素）。 前体食欲素是一种130 aa的肽，具有假定的33 aa分泌序列，疏水核心，其后是带有小极性侧链的残基。 在脑中检测到该表达，在睾丸中检测到很小程度的表达（Sakurai et al.1998）。 这些神经肽结合并激活两个密切相关的食欲素受体-G蛋白偶联受体（GPCR）OX1R和OX2R。
Physical form
含0.1%BSA的PBS液体。
Preparation Note
可以在2-8°C下以未稀释的等分试样冷藏，以供短期使用。 若是保持冷冻在 -20°C 下，未稀释等分试样可保存长达 12 个月。
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Finizia Russo et al.
Anatomical record (Hoboken, N.J. : 2007), 291(2), 169-174 (2008-01-24)
Orexin A (oxA) and orexin B are recently discovered peptides derived from the proteolytic cleavage of the common precursor prepro-orexin. They bind two G protein-coupled receptors, defined orexin 1 (ox1R) and orexin 2 receptor. Both peptides are highly expressed in
Shuqin Zhan et al.
Journal of cellular and molecular medicine, 23(10), 6822-6834 (2019-08-07)
Hypocretin 1 and hypocretin 2 (orexin A and B) regulate sleep, wakefulness and emotion. Tumour necrosis factor alpha (TNF-α) is an important neuroinflammation mediator. Here, we examined the effects of TNF-α treatment on hypocretin expression in vivo and behaviour in
Salvatore Valiante et al.
Journal of anatomy, 222(4), 473-480 (2013-02-22)
The peptides orexin A (OXA) and orexin B, deriving from the cleavage of the precursor molecule prepro-orexin, bind two G-coupled transmembrane receptors, named as receptor 1 (OX1R) and receptor 2 for orexin, showing different affinity-binding properties. First discovered in the
Livia D'Angelo et al.
Anatomical record (Hoboken, N.J. : 2007), 299(8), 1121-1129 (2016-05-26)
Orexin A and B peptides and the receptor OX2R were studied in sea bass and goldfish gastroenteric tract by immunoblotting combined with densitometric analysis using NIH Image J software and immunohistochemical techniques. These teleost species present a different gut organization
Anne Morales et al.
Brain research, 1109(1), 164-175 (2006-08-15)
Orexin-A (OX-A) and -B (OX-B) peptides present in the hippocampus are considered to be exclusively contained in fibers arising from hypothalamus neurons, which were established as the only source of orexins (OXs). Because OX-A is known to exert excitatory actions
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