AB3096
抗促食欲素抗体，前体
Chemicon®, from rabbit
别名:
Anti-NRCLP1, Anti-OX, Anti-PPOX
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Species reactivity:
mouse, human, rat
Citations:
18
Technique(s):
ELISA: suitable
immunohistochemistry: suitable
western blot: suitable
immunohistochemistry: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗促食欲素抗体，前体, Chemicon®, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, human, rat
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PPOX(5498)
Application
抗食欲素抗体，前体是用于ELISA，IH&WB的针对食欲素的抗体。
研究子类别
代谢的CNS控制
昼夜节律性&睡眠
代谢的CNS控制
昼夜节律性&睡眠
研究类别
神经科学
神经科学
蛋白质印迹：使用化学发光技术为1-10μg/mL
ELISA：1：10,000 - 100,000
免疫组化：2-20 μg/mL。
最佳工作稀释度必须由最终用户进行确定。
ELISA：1：10,000 - 100,000
免疫组化：2-20 μg/mL。
最佳工作稀释度必须由最终用户进行确定。
Biochem/physiol Actions
小鼠前体食欲素。 最近已经报告了几种与进食行为有关的肽。 食欲素（食欲素-A和食欲素-B）是在下丘脑中选择性表达的下丘脑神经肽家族（Sakurai et al.1998）。 食欲素-A和食欲素-B通过蛋白水解裂解衍生自相同的前体（前体-食欲素）。 前体食欲素是一种130 aa的肽，具有假定的33 aa分泌序列，疏水核心，其后是带有小极性侧链的残基。 在脑中检测到该表达，在睾丸中检测到很小程度的表达（Sakurai et al.1998）。 这些神经肽结合并激活两个密切相关的食欲素受体-G蛋白偶联受体（GPCR）OX1R和OX2R。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Immunogen
17肽（称为PPOXA11-A）定位在小鼠前体食欲素的C末端附近。
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
含0.1%BSA的PBS液体。
Preparation Note
可以在2-8°C下以未稀释的等分试样冷藏，以供短期使用。 若是保持冷冻在 -20°C 下，未稀释等分试样可保存长达 12 个月。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Luigi Michele Pavone et al.
Anatomical record (Hoboken, N.J. : 2007), 292(2), 202-206 (2008-12-18)
The hypothalamic peptide orexin A (oxA) binds specifically the G-protein-coupled orexin receptor 1 (ox1R). It is involved in many physiological functions including the regulation of food intake, sleep-wake cycle, arterial blood pressure, heart rate, and sexual behavior. The localization of
Finizia Russo et al.
Anatomical record (Hoboken, N.J. : 2007), 291(2), 169-174 (2008-01-24)
Orexin A (oxA) and orexin B are recently discovered peptides derived from the proteolytic cleavage of the common precursor prepro-orexin. They bind two G protein-coupled receptors, defined orexin 1 (ox1R) and orexin 2 receptor. Both peptides are highly expressed in
Shuqin Zhan et al.
Journal of cellular and molecular medicine, 23(10), 6822-6834 (2019-08-07)
Hypocretin 1 and hypocretin 2 (orexin A and B) regulate sleep, wakefulness and emotion. Tumour necrosis factor alpha (TNF-α) is an important neuroinflammation mediator. Here, we examined the effects of TNF-α treatment on hypocretin expression in vivo and behaviour in
E Schéle et al.
Journal of neuroendocrinology, 24(6), 930-943 (2012-02-03)
Interleukin (IL)-6 deficient mice develop mature-onset obesity. Furthermore, i.c.v. administration of IL-6 increases energy expenditure, suggesting that IL-6 centrally regulates energy homeostasis. To investigate whether it would be possible for IL-6 to directly influence the energy homeostasis via hypothalamic regulation
Ming-Fung Wu et al.
Sleep, 46(9) (2023-05-08)
Long-term use of sodium oxybate (SXB), (also called gamma-hydroxybutyrate [GHB]) attenuates the cataplexy and sleepiness of human narcolepsy. We had previously found that chronic opiate usage in humans and long-term opiate administration to mice significantly increased the number of detected
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