产品名称
Anti-Low Density Lipoprotein Antibody, copper oxidized, serum, Chemicon®
biological source
rabbit
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
immunohistochemistry: suitable
western blot: suitable
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... LDLR(3949)
Application
Anti-Low Density Lipoprotein Antibody, copper oxidized is an antibody against Low Density Lipoprotein for use in ELISA, WB, IH.
Research Category
Metabolism
Metabolism
Research Sub Category
Lipid Metabolism & Weight Regulation
Lipid Metabolism & Weight Regulation
Western Blot
Immunohistochemistry: 1:50-1:500
ELISA: 1:500-1:5,000
Optimal working dilutions must be determined by the end user.
Immunohistochemistry: 1:50-1:500
ELISA: 1:500-1:5,000
Optimal working dilutions must be determined by the end user.
Biochem/physiol Actions
Reacts strongly to fully oxidatized modifications of LDL including Cu2+-oxidized LDL, MDA-LDL, HOCL-LDL but not to other oxidized proteins like MDA-HSA, HOCL-HSA, MDA-HDL, HOCL-HDL (below detection limit). The reaction of native LDL was weak, but clearly detectable (approx. 20%). Minimally oxidized LDL gave a strong binding signal (>80%).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Immunogen
Epitope: copper oxidized
Fully Cu2+-oxidized LDL.
Physical form
Rabbit serum. Lyophilized. Contains no preservative. Reconstitute with 100 μL of sterile distilled water.
Preparation Note
Maintain lyophilized material at 2-8°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Malcolm R Ogborn et al.
Lipids, 43(9), 783-791 (2008-07-17)
Conjugated linoleic acid (CLA) is anti-proliferative and anti-inflammatory in the Han:SPRD-cy rat model of kidney disease. We used different doses of CLA and examined effects on renal histological benefit, the renal PPARgamma system and hepatic and renal levels of CLA
Deficiency in the metabolite receptor SUCNR1 (GPR91) leads to outer retinal lesions.
Favret, S; Binet, F; Lapalme, E; Leboeuf, D; Carbadillo, J; Rubic, T; Picard, E; Mawambo et al.
Aging null
Tadashi Uramatsu et al.
Biological & pharmaceutical bulletin, 36(8), 1271-1277 (2013-08-02)
Stroke-prone spontaneously hypertensive (SHRsp) rats develop severe hypertension resulting in renal injury. We investigated apoptosis inhibitor of macrophages (AIM) expression in nephrosclerotic rats and the involvement of AIM in olmesartan (OLM)- and azelnidipine (AZN)-induced decreases in the number of macrophages
Dietary soya protein during pregnancy and lactation in rats with hereditary kidney disease attenuates disease progression in offspring.
Cahill, LE; Peng, CY; Bankovic-Calic, N; Sankaran, D; Ogborn, MR; Aukema, HM
The British Journal of Nutrition null
Malcolm R Ogborn et al.
Kidney international, 64(4), 1214-1221 (2003-09-13)
Conjugated linoleic acid (CLA) describes positional isomers of linoleic acid (LA). Experimental health benefits of CLA include amelioration of malignancy and inflammatory disease and reduction of adiposity. The Han:SPRD-cy rat model of polycystic kidney disease (PKD) features prominent renal interstitial
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