Anti-Potassium Channel KvLQT1 Antibody, CT

KvLQT1(Kv7.1) is a voltage-gated potassium channel protein coded for by the gene KCNQ1. This protein is present in the cell membranes of cardiac muscle tissue and in inner ear neurons among other tissues. KvLQT1 can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3 and in heart cells is required for the repolarization phase of the cardiac action potential. Mutations in the gene are associated with hereditary long QT syndrome, Romano-Ward syndrome, Jervell and Lange-Nielsen syndrome and familial atrial fibrillation, lead to a defective KvLQT1 protein and several forms of inherited arrhythmias known as Long QT syndrome, Short QT syndrome, and Familial Atrial Fibrillation.

This antibody recognizes Potassium Channel KvLQT1 protein.

Epitope: C-terminus

KLH-conjugated linear peptide from the C-terminus of human KvLQT1.

Anti-Potassium Channel KvLQT1 Antibody, C-terminus detects level of Potassium Channel KvLQT1 & has been published & validated for use in IH & WB.

Immunohistochemistry Analysis: 1:300 dilution from a previous lot detected Potassium Channel KvLQT1 in human myocardium tissue.

/Western Blotting Analysis: 2 μg/mL of this
antibody detected KvLQT1 in 10 μg of human
heart tissue lysate.

Optimal working dilutions must be determined by end user.

Research Category
Neuroscience

Research Sub Category
Ion Channels & Transporters

Evaluated by Western Blot in human heart tissue lysate.

Western Blot Analysis: 2 µg/ml of this antibody detected KvLQT1 in 10 µg of human heart tissue lysate.

~ 72 kDa Observed

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
Human heart tissue lysate

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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