AB5932
Anti-Potassium Channel KvLQT1 Antibody, CT
Chemicon®, from rabbit
别名:
IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1, KQT-like 1, Voltage-gated potassium channel subunit Kv7.1, kidney and cardiac voltage dependent K+ channel, potassium voltage-gated channel, KQT-like subfamily, member 1, slow delay
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunohistochemistry
western blot
western blot
Species reactivity:
human
Citations:
13
Technique(s):
immunohistochemistry: suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
Anti-Potassium Channel KvLQT1 Antibody, CT, Chemicon®, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
species reactivity (predicted by homology)
mouse (based on 100% sequence homology), rat (based on 100% sequence homology)
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... KCNQ1(3784)
Analysis Note
Control
Human heart tissue lysate
Human heart tissue lysate
Evaluated by Western Blot in human heart tissue lysate.
Western Blot Analysis: 2 µg/ml of this antibody detected KvLQT1 in 10 µg of human heart tissue lysate.
Western Blot Analysis: 2 µg/ml of this antibody detected KvLQT1 in 10 µg of human heart tissue lysate.
Application
Anti-Potassium Channel KvLQT1 Antibody, C-terminus detects level of Potassium Channel KvLQT1 & has been published & validated for use in IH & WB.
Immunohistochemistry Analysis: 1:300 dilution from a previous lot detected Potassium Channel KvLQT1 in human myocardium tissue.
/Western Blotting Analysis: 2 μg/mL of this
antibody detected KvLQT1 in 10 μg of human
heart tissue lysate.
Optimal working dilutions must be determined by end user.
/Western Blotting Analysis: 2 μg/mL of this
antibody detected KvLQT1 in 10 μg of human
heart tissue lysate.
Optimal working dilutions must be determined by end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Ion Channels & Transporters
Ion Channels & Transporters
Biochem/physiol Actions
This antibody recognizes Potassium Channel KvLQT1 protein.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
KvLQT1(Kv7.1) is a voltage-gated potassium channel protein coded for by the gene KCNQ1. This protein is present in the cell membranes of cardiac muscle tissue and in inner ear neurons among other tissues. KvLQT1 can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3 and in heart cells is required for the repolarization phase of the cardiac action potential. Mutations in the gene are associated with hereditary long QT syndrome, Romano-Ward syndrome, Jervell and Lange-Nielsen syndrome and familial atrial fibrillation, lead to a defective KvLQT1 protein and several forms of inherited arrhythmias known as Long QT syndrome, Short QT syndrome, and Familial Atrial Fibrillation.
~ 72 kDa Observed
Immunogen
Epitope: C-terminus
KLH-conjugated linear peptide from the C-terminus of human KvLQT1.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Lipopolysaccharide-induced inflammation attenuates taste progenitor cell proliferation and shortens the life span of taste bud cells.
Cohn, ZJ; Kim, A; Huang, L; Brand, J; Wang, H
BMC Neuroscience null
Preet S Chadha et al.
British journal of pharmacology, 166(4), 1377-1387 (2012-01-19)
The aim of this study was to characterize the functional impact of KCNQ1-encoded voltage-dependent potassium channels (K(v)7.1) in the vasculature. Mesenteric arteries, intrapulmonary arteries and thoracic aortae were isolated from adult rats. K(v)7.1 channel expression was established by fluorescence immunocytochemistry.
Structural interplay of KV7.1 and KCNE1 is essential for normal repolarization and is compromised in short QT syndrome 2 (KV7.1-A287T).
Ina Rothenberg et al.
HeartRhythm case reports, 2(6), 521-529 (2017-05-12)
Fu Liang Ng et al.
British journal of pharmacology, 162(1), 42-53 (2010-09-16)
KCNQ-encoded voltage-gated potassium channels (K(v) 7) have recently been identified as important anti-constrictor elements in rodent blood vessels but the role of these channels and the effects of their modulation in human arteries remain unknown. Here, we have assessed KCNQ
Akiko Kojima et al.
British journal of pharmacology, 178(13), 2690-2708 (2021-03-26)
The slowly activating delayed rectifier K+ channel (IKs ), composed of pore-forming KCNQ1 α-subunits and ancillary KCNE1 β-subunits, regulates ventricular repolarization in human heart. Propofol, at clinically used concentrations, modestly inhibits the intact (wild-type) IKs channels and is therefore unlikely
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