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Merck
CN

AB5977

Anti-Musashi-1 Antibody

Chemicon®, from rabbit

别名:

Musashi homolog 1

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunocytochemistry
immunohistochemistry
western blot
Species reactivity:
rodent, mouse, rat, human
Citations:
45
Technique(s):
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
Uniprot accession no.:
O43347

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产品名称

Anti-Musashi-1 Antibody, Chemicon®, from rabbit

biological source

rabbit

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rodent, mouse, rat, human

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NM_002442.2

UniProt accession no.

O43347

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... MSI1(4440)

Analysis Note

Control
Mouse cortical neural stem cells (Catalog No. SCR029).
Routinely evaluated by Western Blot on Human Placenta lysates.

Western Blot Analysis:
1:1000 dilution of this lot detected Musashi-1 on 10 μg of Human placenta lysates.

Application

Detect Musashi-1 using this Anti-Musashi-1 Antibody validated for use in IC, IH & WB.
Immunohistochemistry:
1:200-1:1,000 dilution from a previous lot was used.

Immunocytochemistry:
1:200-1:1,000 dilution from a previous lot was used.

Western blot:
1:200-1:1,000 using ECL.

Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Research Sub Category
Neuronal & Glial Markers

Developmental Neuroscience

RNA Binding Protein (RBP)

Biochem/physiol Actions

Reactivity with other species has not been confirmed.
Recognizes Musashi-1.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

39 kDa
In mammals, the Musashi family is important for cell fate determination, playing roles in maintenance of the stem-cell state, differentiation and tumorigenesis. Musashi1 (also known as Msi1), is selectivley expressed in neural progenitor cells, including neural stem cells. Outside the nervous system, Musashi1 is a selective marker for intestinal stem or early lineage cells. Musashi1 interacts with the Notch pathway during asymmetric cell division by binding the 3′ UTR of Numb. Numb is prevented from repressing Notch signaling when Musashi1 is present.

Immunogen

Synthetic peptide, amino acids 5-21 of Musashi.

Other Notes

Replaces: 03-114; 04-1041

Physical form

ImmunoAffinity Purified
Purified rabbit polyclonal in buffer containing a solution of 50% saturated ammonium sulfate and PBS containing no preservatives.

Preparation Note

Stable for 1 year at -80ºC from date of receipt.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Cell lineage identification and stem cell culture in a porcine model for the study of intestinal epithelial regeneration.
Gonzalez, LM; Williamson, I; Piedrahita, JA; Blikslager, AT; Magness, ST
Testing null
Musashi1-CreER(T2) : a new cre line for conditional mutagenesis in neural stem cells.
Takeda, H; Koso, H; Tessarollo, L; Copeland, NG; Jenkins, NA
Genesis (2000)
Marten Rehfeld et al.
Journal of cancer research and clinical oncology, 147(10), 2969-2982 (2021-06-26)
The identification of prognostically and therapeutically relevant molecular markers is fundamental to the further development of personalised therapies in brain tumours. Current therapeutic options for the treatment of gliomas rely mainly on surgical resection and the inhibition of tumour cell
Raffaella Scardigli et al.
Stem cells (Dayton, Ohio), 32(9), 2516-2528 (2014-05-09)
Adult neurogenesis is a multistep process regulated by several extrinsic factors, including neurotrophins. Among them, little is known about the role of nerve growth factor (NGF) in the neurogenic niches of the mouse. Here we analyzed the biology of adult
Lisa Arvidsson et al.
PloS one, 6(11), e27393-e27393 (2011-11-19)
Filum terminale (FT) is a structure that is intimately associated with conus medullaris, the most caudal part of the spinal cord. It is well documented that certain regions of the adult human central nervous system contains undifferentiated, progenitor cells or
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RNA-Binding Protein Immunoprecipitation

All eukaryotic organisms require tight regulation of gene expression for complex processes such as development, differentiation, cell specification, and responses to environmental stimuli. Many genes are regulated post-transcriptionally, in addition to transcriptional mechanisms of gene regulation. RNA-binding proteins (RBPs) are essential for post-transcriptional gene regulation, linking transcription and translation in many processes including transcription, splicing, export, rate of translation and turnover. In all of these events, RBPs coordinate regulation of the amount of protein produced from mRNA transcripts.

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