biological source
rabbit
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
sheep, rat, mouse
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable, radioimmunoassay: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
Immunogen
Peptide from mouse kisspeptin 10. The sequence is common to all kisspeptin isoforms.
Application
Anti-Kisspeptin Antibody detects level of Kisspeptin & has been published & validated for use in IH, RIA.
Immunohistochemistry on 4% paraformaldehyde fixed tissue: 1:500-1:1,000 (PAP and ABC with NiDAB detection system).
RIA: 1:500-1:10,000
Optimal working dilutions must be determined by the end user.
RIA: 1:500-1:10,000
Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Hormones & Receptors
CNS Control of Metabolism
Hormones & Receptors
CNS Control of Metabolism
Biochem/physiol Actions
Kisspeptin 10 (kp10, metastin). No cross reactivity with GnRH, Galatin, SP, NPY, CRH, alphaMSH, SRIF or PrRP by RIA.
The antibody showed a very low level of reactivity with human kp10.
Physical form
Rabbit serum.Liquid containing 50% glycerol, Ph 7.4, Phosphate buffer 0.01M.
Serum
Preparation Note
Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 2
法规信息
新产品
此项目有
R M Cravo et al.
Neuroscience, 173, 37-56 (2010-11-26)
Humans and mice with loss-of-function mutations of the genes encoding kisspeptins (Kiss1) or kisspeptin receptor (Kiss1r) are infertile due to hypogonadotropic hypogonadism. Within the hypothalamus, Kiss1 mRNA is expressed in the anteroventral periventricular nucleus (AVPV) and the arcuate nucleus (Arc).
Characterisation of Arcuate Nucleus KisspeptinNeurokinin B Neuronal Projections and Regulation during Lactation in the Rat.
True C
Journal of Neuroendocrinology null
Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha.
Franceschini, I, et al.
Neuroscience Letters, 401, 225-230 (2006)
Leptin deficiency and diet-induced obesity reduce hypothalamic kisspeptin expression in mice.
Quennell, JH; Howell, CS; Roa, J; Augustine, RA; Grattan, DR; Anderson, GM
Endocrinology null
Arcuate kisspeptin/neurokinin B/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weight.
Mittelman-Smith, MA; Williams, H; Krajewski-Hall, SJ; Lai, J; Ciofi, P; McMullen, NT; Rance, NE
Endocrinology null
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