ABC257
Anti-EPHB4 Antibody
from rabbit, purified by affinity chromatography
别名:
Ephrin type-B receptor 4, Hepatoma transmembrane kinase, Tyrosine-protein kinase TYRO11
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
species reactivity (predicted by homology)
mouse (based on 100% sequence homology), bovine (based on 100% sequence homology), rat (based on 100% sequence homology)
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... EPHB4(2050)
General description
Ephrin type-B receptor 4 (EPHB4) is also called Hepatoma transmembrane kinase, and Tyrosine-protein kinase TYRO11. EPHB4 is a receptor tyrosine kinase that together with EFNB2 is critical to heart morphogenesis and angiogenesis through the regulation of cell adhesion and cell migration. EPHB4 is expressed in placenta, kidney, liver, lung, pancreas, skeletal muscle, and heart, as well as primitive and myeloid hematopoietic cells.
~120 kDa observed. The calculated molecular weight is 108 kDa, however EPHB4 has been shown as a ~120 kDa band in western blots (Lee, Y. C., et al. (2005). BMC Cancer. 5(119):1-11).
Immunogen
KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human EPHB4.
Application
Detect EphB4 using this rabbit polyclonal antibody, Anti-EPHB4 Antibody validated for use in western blotting.
Analysis Note
Evaluated by Western Blotting in PC3 tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected EPHB4 in 10 µg of PC3 tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected EPHB4 in 10 µg of PC3 tissue lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
José Carlos Rivera et al.
Investigative ophthalmology & visual science, 56(13), 7897-7907 (2015-12-17)
This study evaluated the effects of BIBF1120, a novel triple angiokinase inhibitor against pathological retinal neovascularization. BIBF1120 effect on development of the normal retinal vasculature was evaluated in Sprague-Dawley rat pups. Two models of ischemic oxygen-induced retinopathy (OIR) and the
Ling-Dan Dong et al.
Oncology letters, 13(4), 2109-2114 (2017-04-30)
Endometrial adenocarcinoma (EC) is one of the most frequently diagnosed types of endometrial cancer and is typically a consequence of continuous estrogen receptor stimulation. Erythropoietin-producing hepatocyte receptor B4 (EphB4) and its ligand ephrin-B2 have been reported to be overexpressed in
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