Anti-ACVR1 Antibody

Activin receptor type-1 (ACVR1) is a member of the protein kinase superfamily, and more specifically to the TKL Ser/Thr protein kinase family and TGFB receptor subfamily. Activins are growth and differentiation factors that belong to the transforming growth factor-beta (TGF-beta) superfamily. ACVR1 plays a role in ligand binding and forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. The process of forming this receptor complex involves the phosphorylation of Type II receptors; the activation of Type I receptors; the autophosphorylation of Type I receptors, which then bind and activate SMAD transcriptional regulators. ACVR1 is expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells. Furthermore, ACVR1 is shown to interact with FKBP1A and FCHO1. Defects in ACVR1 are a cause of fibrodysplasia ossificans progressiva (FOP) - a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. Additionally, ACVR1 may play a role in the left-right pattern formation during embryogenesis.

~43 kDa observed. Uncharacterized bands may appear in some lysate(s).

KLH-conjugated linear peptide corresponding to human ACVR1.

Anti-ACVR1 Antibody is a highly specific rabbit polyclonal antibody, that targets Activin receptor type-1 & has been tested in IHC.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

This antibody recognizes the N-terminus of ACVR1.

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
Human prostate carcinoma and breast cancer tissue

Evaluated by Immunohistochemistry in human prostate carcinoma and breast cancer tissue.

Immunohistochemistry Analysis: A 1:50-1,000 dilution from a representative lot detected ACVR1 in human prostate carcinoma and breast cancer tissue.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.