Anti-RICK Antibody

Receptor-interacting serine/threonine-protein kinase 2 (RIPK2), also known as CARD-containing interleukin-1 beta-converting enzyme-associated kinase (CARDIAK), RIP-like-interacting CLARP kinase, Receptor-interacting protein 2 (RIP-2), and Tyrosine-protein kinase RIPK2, is a member of the TKL Ser/Thr family. RICK is a serine/threonine/tyrosine kinase that has been shown to play an important role in modulation of innate and adaptive immune responses. Studies have indicated that RICK may play an essential role in immune response, growth control, and apoptosis. It is also suggested to play a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation. RICK interacts with members of the TRAF family, CLARP and caspase-1 and is implied to regulate TNF and Fas induced-apoptosis, which is involved in the generation of proinflammatory cytokine IL-1beta. RICK is expressed in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.

~61 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 2 isoforms at ~46 kDa and ~61 kDa

Epitope: N-terminus

KLH-conjugated linear peptide corresponding to the N-terminus of human RICK.

Anti-RICK Antibody is a highly specific rabbit polyclonal antibody, that targets RICK & has been tested in western blotting & ICC.

Immunocytochemistry Anlaysis: 10 µg/mL from a representative lot detected RICK in A431 cells.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

This antibody recognizes the N-terminus of RICK.

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
A431 and K562 cell lysates

Evaluated by Western Blotting in A431 and K562 cell lysates.

Western Blotting Analysis: 1 µg/mL of this antibody detected RICK in 15 µg of A431 and K562 cell lysates.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.