产品名称
抗-c-Fos抗体, from rabbit, purified by affinity chromatography
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human, rat
species reactivity (predicted by homology)
sheep (based on 100% sequence homology), mouse (based on 100% sequence homology), bovine (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), porcine (based on 100% sequence homology)
technique(s)
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... FOS(2353)
Analysis Note
对照
PMA（TPA）处理的HeLa细胞裂解物
PMA（TPA）处理的HeLa细胞裂解物
通过蛋白质印迹在PMA（TPA）处理的HeLa细胞裂解物中的进行了评估。
蛋白质印迹分析：0.5 µg/mL该抗体在10 µg PMA（TPA）处理的HeLa细胞裂解物中检测到c-Fos。
蛋白质印迹分析：0.5 µg/mL该抗体在10 µg PMA（TPA）处理的HeLa细胞裂解物中检测到c-Fos。
Application
免疫组化分析： 代表性批次的1：1,000稀释液在大鼠脑桥和大鼠小脑组织中检测到c-Fos。
免疫荧光分析： 代表性批次在大鼠脑桥和大鼠小脑组织中检测到c-Fos。
免疫荧光分析： 代表性批次在大鼠脑桥和大鼠小脑组织中检测到c-Fos。
抗c-Fos抗体是一种用于检测c-Fos的兔多克隆抗体，也称为原癌基因c-Fos，细胞癌基因fos&已在WB &IHC中得到验证。
Biochem/physiol Actions
该抗体识别c-Fos的N末端。
General description
c-Fos是也被鉴定为原癌基因的立即早期基因（IEG）转录因子家族的成员（其他成员包括Jun和Egr-1）。c-Fos和其他IEG的基础表达通常较低，但响应通常由外部刺激（例如应激或神经元激活）引起的细胞活性变化而相对快速且通常急剧增加（mRNA为15-30分钟；蛋白为30-60分钟）。因此，这些IEG用于指示比活驱动的细胞活化，包括鉴别由各种生长因子、神经活性药物激活的神经元以及行为或生理状态的相关变化。
观察值〜60/56 kDa。 该蛋白具有通过53和68kDa范围内的选择性剪接产生的多种亚型（Jurado, J., et al. (2007).BMC Molecular Biology.8:83-96.)
Immunogen
对应于人c-Fos N末端的KLH偶联的线性肽。
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Isabel F Augur et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(39), 10174-10180 (2016-09-30)
The ventromedial prefrontal cortex (vmPFC) has been shown to negatively regulate cocaine-seeking behavior, but the precise conditions by which vmPFC activity can be exploited to reduce cocaine relapse are currently unknown. We used viral-mediated gene transfer of designer receptors (DREADDs)
Anett J Nagy et al.
PLoS biology, 16(6), e2004712-e2004712 (2018-06-26)
Evolutionary development of vision has provided us with the capacity to detect moving objects. Concordant shifts of visual features suggest movements of the observer, whereas discordant changes are more likely to be indicating independently moving objects, such as predators or
Min-Yu Sun et al.
Scientific reports, 9(1), 16431-16431 (2019-11-13)
Pentameric GABAA receptors mediate a large share of CNS inhibition. The γ2 subunit is a typical constituent. At least 11 mutations in the γ2 subunit cause human epilepsies, making the role of γ2-containing receptors in brain function of keen basic
Ozra Dehkordi et al.
Journal of alcoholism and drug dependence, 5(4) (2017-10-19)
Orexin/hypocretin-containing neurons in lateral hypothalamus (LH) are implicated in the neurobiology of nicotine addiction. However, the neuroanatomical relationships between orexin-neurons/nerve fibers and nicotine-activated cells within the reward-addiction neurocircuitry is not known. In the present study in mice, we first used
Giuseppe Giannotti et al.
Scientific reports, 9(1), 10709-10709 (2019-07-26)
The prefrontal cortex is an important regulator of fear expression in humans and rodents. Specifically, the rodent prelimbic (PL) prefrontal cortex drives fear expression during both encoding and retrieval of fear memory. Neuronal ensembles have been proposed to function as
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