T-cell immunoglobulin and mucin domain-containing protein 1 (TIMD-1, TIM-1, TIM, TIM1, TIMD1), also known as Hepatitis A virus cellular receptor 1 (HAVcr-1) and Kidney injury molecule 1(KIM-1, KIM1), may play an important role in T-helper cell development and the regulation of asthma and allergic diseases. In the case of human hepatitis A virus (HHAV) infection, HAVcr-1 functions as a cell-surface receptor for the virus, through which the hepatitis A virus can gain entry into a cell. Additional evidence implies that it may play a role in kidney injury and repair. HAVcr-1 is widely expressed, with highest levels in kidney and testis. It is also expressed by activated CD4+ T-cells during the development of helper T-cells responses. Furthermore, HAVcr-1 is expressed on T helper 2 (Th2) cells of the immune system, and following the binding of its natural ligand TIM-4, stimulates T cell expansion and cytokine production in response to viral challenge.

~59 kDa observed. Uniprot describes a molecular weight at 38 kDa However, this protein has been observed at ~59 kDa (Thompson, P., et al. (1998). J Virol. 72(5):3751-3761.).

KLH-conjugated linear peptide corresponding to human HAVcr-1.

Detect HAVcr-1 using this Anti-HAVcr-1 Antibody validated for use in western blotting & flow cytometry.

Flow Cytometry Analysis: 1 µg from a representative lot detected HAVcr-1 in 1X10E6 769-P cells.

Research Category
Inflammation & Immunology

Research Sub Category
Inflammation & Autoimmune Mechanisms

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Evaluated by Western Blotting in human spleen tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected HAVcr-1 in 10 µg of human spleen tissue lysate.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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