ABN1456
Anti-IAPP
from rabbit, purified by affinity chromatography
别名:
Amylin, Diabetes associated peptide, DAP, Insulinoma amyloid peptide
产品名称
Anti-IAPP, from rabbit, purified by affinity chromatography
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
technique(s)
immunohistochemistry: suitable (paraffin)
NCBI accession no.
UniProt accession no.
shipped in
ambient
target post-translational modification
unmodified
Quality Level
Gene Information
human ... IAPP(3375)
Analysis Note
Evaluated by Immunohistochemistry in human pancreas tissue.
Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected IAPP in human pancreas tissue.
Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected IAPP in human pancreas tissue.
Application
Anti-IAPP, Cat. No. ABN1456, is a highly specific rabbit polyclonal antibody that targets Islet amyloid polypeptide and has been tested in Immunohistochemistry (Paraffin).
Biochem/physiol Actions
This polyclonal antibody detects IAPP in human pancreatic tissue.
General description
9.8 kDa calculated
Islet amyloid polypeptide (UniProt: P10997; also known as Amylin; Diabetes-associated peptide; DAP; Insulinoma amyloid peptide, IAPP) is encoded by the IAPP gene (Gene ID: 3375) in human. IAPP is a secreted peptide that is degraded by insulin degrading enzyme (IDE). IAPP is a major constituent of amyloid deposits in pancreatic islets, characteristic histopathology for type 2 diabetes. The mature IAPP is largely unstructured in the absence of a cognate ligand, and has a strong tendency to form fibrillar aggregates. In diabetic islets, water-soluble IAPP is shown to disappear in beta-cell granules and is transformed to water-insoluble amyloid deposits that can initiate beta cell necrosis. Oligomers of human IAPP can form toxic oligomers and induce apoptosis in cultured pancreatic cells. IAPP is shown to selectively inhibit insulin-stimulated glucose utilization and glycogen deposition in muscle, but does not affect adipocyte glucose metabolism. (Ref.: Bram, Y., et al. (2014). Scientific Reports 4, Article number: 4267; Tomita, T. (2012). Islets. 4(3): 223 232).
Immunogen
A KLH-conjugated linear peptide from an internal region of human islet amyloid polypeptide.
Other Notes
Concentration: Please refer to lot specific datasheet.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
法规信息
新产品
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Guoxin Zhang et al.
Molecular neurodegeneration, 17(1), 12-12 (2022-01-31)
The pathologic accumulation and aggregation of tau is a hallmark of tauopathies including Alzheimer's disease (AD). However, the molecular mechanisms mediating tau aggregation in AD remain elusive. The incidence of AD is increased in patients with type 2 diabetes (T2DM)
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