ABN241
抗-GluR1抗体
from rabbit, purified by affinity chromatography
别名:
Glutamate receptor 1, GluR-1, AMPA-selective glutamate receptor 1, GluR-A, GluR-K1, Glutamate receptor ionotropic, AMPA 1, GluA1
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
human, mouse, rat
技术
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... GRIA1(2890)
mouse ... Gria1(14799)
rat ... Gria1(50592)
一般描述
谷氨酸受体（GluRs）是一个多样化的群体，负责介导脊椎动物中枢神经系统中的大多数兴奋性突触传递。它们可以分为离子型或代谢型，并可再根据其激动剂的偏好型（NMDA、AMPA或红藻氨酸）而进一步分类。存在有四种类型的AMPA选择性GluR亚基（GluR1、GluR2、GluR3和GluR4）。不同亚基的四聚体或五聚体组合有助于AMPA受体的功能多样性。AMPA受体可在大多数兴奋性突触中介导快速突触电流，具有以亚型组成为特征的化学计量。控制钙渗透性的关键残基位于孔环区域。在GluR1、GluR3和GluR4中，该位置被一个Gln残基所占据。从突触后膜插入或去除GluR1/GluR4寡聚通道似乎是LTP/LTD活性依赖性的，而GluR2/GluR3寡聚体不断循环。
观察值〜110 kDa
免疫原
对应于大鼠GluR1胞外域的KLH偶联线性肽。
应用
免疫组化分析：代表性批次的1：1,000 的稀释液在人大脑和人小脑组织中检测到GluR1。
抗GluR1抗体是一种高度特异性的兔多克隆抗体，其靶向GluR1&已在蛋白质印迹& IHC（石蜡）中进行了测试。
生化/生理作用
该抗体识别GluR1的胞外域。
分析说明
通过蛋白质印迹对大鼠脑组织裂解液进行了评估。
蛋白质印迹分析：2.0 µg/mL该抗体在10 µg大鼠脑组织裂解液中检测到GluR1。
蛋白质印迹分析：2.0 µg/mL该抗体在10 µg大鼠脑组织裂解液中检测到GluR1。
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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Certain individuals, here referred to as Non-Demented with Alzheimer Neuropathology (NDAN), do not show overt neurodegeneration (N-) and remain cognitively intact despite the presence of plaques (A+) and tangles (T+) that would normally be consistent with fully symptomatic Alzheimer's disease
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