Sushi-repeat-containing protein X-linked 2 (SRPX2) is a neural gene associated with the speech and language centers of the human brain. SRPX2 mutations can lead to epilepsy, speech dyspraxia, mental retardation and cognitive disorders. SRPX2 has been shown to mediate angiogenesis and acts as a ligand for the urokinase-type plasminogen activator, which facilitates invasive migration of sprouting endothelial cells. SRPX2 is highly expressed in brain, neurons, placenta, lung, trachea, uterus and adrenal gland; and weakly expressed in the peripheral blood, brain and bone marrow. SRPX2 is also expressed in numerous cancer cell lines, including overexpressed in gastric cancer, increasing phosphorylation levels of focal adhesion kinase, and enhanced cellular migration and adhesion, indicating that SRPX2 may be a useful target in the treatment of metastatic cancers.

KLH-conjugated linear peptide corresponding to human SRPX2.

Anti-SRPX2 Antibody is a highly specific rabbit polyclonal antibody, that targets Sushi-repeat-containing protein X-linked 2 & has been tested in western blotting & IHC.

Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected SRPX2 in rat lung tissue.

Research Category
Neuroscience

Research Sub Category
Sensory & PNS

Evaluated by Western Blotting in human lung tissue lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected SRPX2 in 15 µg of human lung tissue lysate.

~55 kDa observed. Uncharacterized bands may appear in some lysate(s).

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
Human lung tissue lysate

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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