ABS186
Anti-Spred-1 Antibody
from rabbit, purified by affinity chromatography
别名:
Sprouty-related, EVH1 domain-containing protein 1, Spred-1, hSpred1
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, human
species reactivity (predicted by homology)
rat (based on 100% sequence homology)
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... SPRED1(161742)
General description
Spred1 is a tyrosine kinase substrate which has a cysteine-rich domain which resembles the SPR domain at the carboxy terminus. Spred1 associated with Ras, blocks phosphorylation of Raf and disrupts MAP kinase signaling during the differentiation of neuronal cells and myocytes. A mutation in Spred1 has been linked to Lugius syndrome, an autosomal dominant RAS-MAPK pathway syndrome.
~50 kDa observed
Immunogen
KLH-conjugated linear peptide corresponding to human Spred-1.
Application
Anti-Spred-1 Antibody is an antibody against Spred-1 for use in WB.
Research Category
Signaling
Signaling
Research Sub Category
Growth Factors & Receptors
Growth Factors & Receptors
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blot in HEK293 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Spred-1 on 10 µg of HEK293 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Spred-1 on 10 µg of HEK293 cell lysate.
Control
HEK293 cell lysate
HEK293 cell lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Zhiyong Lei et al.
Journal of cellular and molecular medicine, 19(8), 1994-2005 (2015-05-07)
Arteriogenesis is a complicated process induced by increased local shear-and radial wall-stress, leading to an increase in arterial diameter. This process is enhanced by growth factors secreted by both inflammatory and endothelial cells in response to physical stress. Although therapeutic
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