Cyclin-dependent kinase-like 5 (CDKL5) is a serine/threonine-protein kinase that mediates phosphorylation of Methyl-CpG-binding protein 2 (MECP2). MECP2 is a chromosomal protein that binds to methylated DNA, specifically to a single methyl-CpG pair. MECP2 mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A.

~ 115 kDa observed

GST-tagged recombinant protein corresponding to mouse CDKL5 near the N-terminus.

Anti-CDKL5 NT Antibody is a highly specific rabbit polyclonal antibody, that targets Cyclin-dependent kinase-like 5 & has been tested in western blotting.

Western Blotting Analysis: A representative lot detected CDKL5 in mouse brain tissue expressing wild type CDKL5 and not in mouse brain tissue expressing knockout CDKL5.

Evaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected CDKL5 in 10 µg of rat brain tissue lysate.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.