ABT114
Anti-LPA receptor 5 Antibody (GPR92)
from rabbit, purified by affinity chromatography
别名:
Lysophosphatidic acid receptor 5, LPA receptor 5, LPA-5, G-protein coupled receptor 92, G-protein coupled receptor 93
产品名称
Anti-LPA receptor 5 Antibody (GPR92), from rabbit, purified by affinity chromatography
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human, mouse
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... LPAR5(57121)
Analysis Note
Control
K562 cell lysate
K562 cell lysate
Evaluated by Western Blot in K562 cell lysate.
Western Blot Analysis: 0.2 µg/mL of this antibody detected LPA receptor 5 on 10 µg of K562 cell lysate.
Western Blot Analysis: 0.2 µg/mL of this antibody detected LPA receptor 5 on 10 µg of K562 cell lysate.
Application
Detect the LPA receptor 5 protein using this Anti-LPA receptor 5 (GPR92) validated for use in WB.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Adhesion (CAMs)
Adhesion (CAMs)
Western Blot Analysis: A representative lot detected LPA receptor 5 in non-transfected CHEM-1 cells and CHEM-1 cells transfected with LPAR5(GPR92) (Catalogue. No. HTS209C - Transfected Cell Line).
Immunocychemistry Analysis: A 1:500 dilution from a representative lot detected LPAR5 in TF1 cells, non-transfected CHEM-1 cells and CHEM-1 cells transfected with LPAR5(GPR92) (Catalogue. No. HTS209C - Transfected Cell Line).
NOTE: The protein used to make the transfected CHEM1 cell line is full length LPAR5.
Immunocychemistry Analysis: A 1:500 dilution from a representative lot detected LPAR5 in TF1 cells, non-transfected CHEM-1 cells and CHEM-1 cells transfected with LPAR5(GPR92) (Catalogue. No. HTS209C - Transfected Cell Line).
NOTE: The protein used to make the transfected CHEM1 cell line is full length LPAR5.
Biochem/physiol Actions
This antibody recognizes the extracellular domain of LPA receptor 5.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Lysophosphatidic acid receptor 5 (LPA receptor 5), also known as GPR92, is a G12/13 and Gq coupled receptor that mediates the signaling of LPA. Ligand binding to LPA receptor 5 may increase intracellular levels of cAMP and calcium, resulting in the activation of a wide range of effector molecules. Recent studies have demonstrated that LPA receptor 5 is abundantly expressed in human mast cells, and mediates the release of the macrophage inflammatory protein-1β (MIP-1β), indicating that LPA receptor 5 may play a role in innate and adaptive immunity.
~37 kDa observed. The calculated molecular weight of this protein is 41 kDa, but can be observed at ~60 kDa due to high glycosylation.
Immunogen
Epitope: Extracellular domain
KLH-conjugated linear peptide corresponding to the extracellular domain of human LPA receptor 5.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Camila O de Souza et al.
The Journal of clinical investigation, 132(21) (2022-09-07)
The molecular mechanisms underlying obesity-induced increases in β cell mass and the resulting β cell dysfunction need to be elucidated further. Our study revealed that GPR92, expressed in islet macrophages, is modulated by dietary interventions in metabolic tissues. Therefore, we
Lisha Joshi et al.
International journal of molecular sciences, 22(16) (2021-08-28)
Increasing evidence suggests that systemic inflammation triggers a neuroinflammatory response that involves sustained microglia activation. This response has deleterious consequences on memory and learning capability in experimental animal models and in patients. However, the mechanisms connecting systemic inflammation and microglia
Feng Liu et al.
iScience, 26(8), 107465-107465 (2023-08-21)
Soluble epoxide hydrolase is a widely distributed bifunctional enzyme that contains N-terminal phosphatase (N-phos) and C-terminal epoxide hydrolase (C-EH) domains. C-EH hydrolyzes anti-inflammatory epoxy-fatty acids to corresponding diols and contributes to various inflammatory conditions. However, N-phos has been poorly examined. In
Maria Nunez-Salces et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 32(12), e13944-e13944 (2020-07-16)
The ability of the gut to detect nutrients is critical to the regulation of gut hormone secretion, food intake, and postprandial blood glucose control. Ingested nutrients are detected by specific gut chemosensors. However, knowledge of these chemosensors has primarily been
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