ABT48
Anti-Vesicle protein sorting 35 (VPS35) Antibody
from rabbit
别名:
vacuolar protein sorting 35 homolog (S. cerevisiae), vacuolar protein sorting 35, Maternal-embryonic 3, vacuolar protein sorting 35 (yeast homolog), vacuolar protein sorting 35 (yeast), Vesicle protein sorting 35
产品名称
Anti-Vesicle protein sorting 35 (VPS35) Antibody, from rabbit
biological source
rabbit
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, rat, mouse
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... VPS35(55737)
Analysis Note
Control
A431 cell lysate
A431 cell lysate
Evaluated by Western Blot in A431 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected VPS35 in 10 µg of A431 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected VPS35 in 10 µg of A431 cell lysate.
Application
Anti-Vesicle protein sorting 35 (VPS35) Antibody is an antibody against Vesicle protein sorting 35 (VPS35) for use in WB.
RNAi: A previous lot of antibody was used in siRNA knockdown experiments by an independent laboratory (Courtesy of Gomez, TS, Mayo Clinic, 2010).
Research Category
Cell Structure
Cell Structure
Research Sub Category
Cytoskeletal Signaling
Cytoskeletal Signaling
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Vacuolar protein sorting-associated protein 35 (VPS35) is critical component found within the retromer complex. The retromer complex is comprised of several proteins and has been implicated in roles involving the Wnt signaling pathway, cell migration and adhesion, and polymeric immunoglobulin A transcytosis. VPS35 plays an essential role in the selection and trafficking of lysosomal enzyme receptors from endosomes to the Golgi. It is also a required component for the secretion of active Wnt. Expression of VPS35 is pervasive throughout all tissue. Highest levels of expression have been observed in brain, colon, heart, kidney, ovary, placenta, skeletal muscle, small intestine, spleen, testis, and thymus.
~ 80 kDa observed MW. Expected MW is 92 kDa
Immunogen
GST-tagged recombinant protein corresponding to human VPS35.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Format: Purified
Protein G
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl, with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Elpida Tsika et al.
Human molecular genetics, 23(17), 4621-4638 (2014-04-18)
Mutations in the vacuolar protein sorting 35 homolog (VPS35) gene at the PARK17 locus, encoding a key component of the retromer complex, were recently identified as a new cause of late-onset, autosomal dominant Parkinson's disease (PD). Here we explore the
Mian Cao et al.
Neuron, 93(4), 882-896 (2017-02-24)
Synaptojanin 1 (SJ1) is a major presynaptic phosphatase that couples synaptic vesicle endocytosis to the dephosphorylation of PI(4,5)P2, a reaction needed for the shedding of endocytic factors from their membranes. While the role of SJ1's 5-phosphatase module in this process
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