产品名称
ADAM 17, control peptide for AB19027,
biological source
human
form
liquid
manufacturer/tradename
Chemicon®
concentration
200 μg/mL
technique(s)
inhibition assay: suitable (peptide)
NCBI accession no.
UniProt accession no.
shipped in
dry ice
Quality Level
General description
The peptide is used for blocking the activity of anti-TACE, C-Terminal (Catalog number AB19027). Incubate the peptide with equal volume of antibody for 30 minutes at 37oC to block the activity of anti-TACE in Western blotting. Amino Acids 807 to 823 (ASFKLQRQNRVDSKETE) of human TACE (Black et al. 1997; Moss et al. 1997).
Application
For use in blocking the reactivity of AB19027.
Optimal working dilution must be determined by the end user.
Optimal working dilution must be determined by the end user.
Physical form
Liquid in PBS containing 0.1% BSA and 0.02% sodium azide.
Preparation Note
Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
M L Moss et al.
Nature, 385(6618), 733-736 (1997-02-20)
Tumour-necrosis factor-alpha (TNF-alpha) is a cytokine that contributes to a variety of inflammatory disease states. The protein exists as a membrane-bound precursor of relative molecular mass 26K which can be processed by a TNF-alpha-converting enzyme (TACE), to generate secreted 17K
R A Black et al.
Nature, 385(6618), 729-733 (1997-02-20)
Mammalian cells proteolytically release (shed) the extracellular domains of many cell-surface proteins. Modification of the cell surface in this way can alter the cell's responsiveness to its environment and release potent soluble regulatory factors. The release of soluble tumour-necrosis factor-alpha
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