Neurotrophin 4/5

Neurotrophin-4 (NT-4/NT-5) is a potent neurotrophic factor which supports the growth and survivability of nerve and/or glial cells. The active form of human NT-4 is a dimer, formed by two identical 130 amino acid subunits, which is held together by strong hydrophobic interactions.

Product Source: Human NT4/5 expressed in E.coli

Concentration range for most in vitro applications is 0.5 to 100 ng/mL. Responding cells include (partial list): Nerve, glial cells.

The lyophilized powder, though stable at room temperature, is best stored desiccated below 0°C for up to 12 months after date of receipt. After a quick spin, reconstitute with sterile water to a concentration of 0.1-1.0 mg/mL. This solution can be diluted into other aqueous buffers. Reconstitute NT-4 should be stored in undiluted aliquots at -20°C for up to six months.

Specific Activity: Chemicon′s human NT-4 is fully biologically active when compared to standards. The ED(50) as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cultures.

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