产品名称
Anti-TIMP-3 Mouse mAb (136-13H4), liquid, clone 136-13H4, Calbiochem®
biological source
mouse
antibody product type
primary antibodies
clone
136-13H4, monoclonal
form
liquid
contains
≤0.1% sodium azide as preservative
species reactivity
human, baboon, rabbit
should not react with
chicken, porcine, rat, bovine
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
isotype
IgG1
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TIMP3(7078)
Analysis Note
Positive Control
293 or Caco-2 cells or unfixed eye tissue
293 or Caco-2 cells or unfixed eye tissue
Application
Frozen sections (2-10 g/ml)
Immunoblotting (5 g/ml)
Immunofluorescence (not recommended)
Immunoprecipitation (not recommended)
Paraffin sections (10 g/ml, heat pre-treatment required, see application references)
Disclaimer
Toxicity: Standard Handling (A)
General description
Mouse monoclonal antibody generated by immunizing mice with the specified immunogen and fusing splenocytes with NS1 mouse myeloma cells (see application references). Recognizes both the ~27 kDa glycosylated and the ~24 kDa unglycosylated forms of TIMP-3.
Recognizes the ~27 kDa glycosylated and the ~24 kDa non-glycosylated forms of TIMP-3. Does not cross-react with TIMP-1 or TIMP-2 in CaCO-2 and HEK293 cell and eye tissue.
This Anti-TIMP-3 Mouse mAb (136-13H4) is validated for use in Frozen sections, Immunoblotting, Immunofluorescence, Immunoprecipitation, Paraffin sections for the detection of TIMP-3.
Immunogen
Human
a synthetic peptide corresponding to amino acids 170-188 of human TIMP-3
Legal Information
Manufactured by Daiichi Fine Chemical Co., Ltd. Not available for sale in Japan.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Anand-Apte, B., et al. 1997. Invest. Ophthalmol. Vis. Sci.38, 817.
Butler, G.S., et al. 1997. Eur. J. Biochem.244, 653.
Fariss, R.N., et al. 1997. Am. J. Pathol.150, 323.
Vranka, J.A., et al. 1997. Curr. Eye Res.16, 102.
Ruiz, A., et al. 1996. Biochem. Biophys. Res. Commun.226, 467.
Kishnani, N.S., et al. 1995. Matrix Biol.14, 479.
Cottam, D.W. and Rees, R.C. 1993. Intl J. Oncol.2, 861.
Stetler-Stevenson, W. G., et al. 1993. FASEB J.7, 1434.
Woessner, J.F. 1991. FASEB J.5, 2145.
Liotta, L.A. and Stetler-Stevenson, W.G. 1990. in Seminars in Cancer Biology, ed. M. M. Gottesman. Vol. 1(2), 99.
Butler, G.S., et al. 1997. Eur. J. Biochem.244, 653.
Fariss, R.N., et al. 1997. Am. J. Pathol.150, 323.
Vranka, J.A., et al. 1997. Curr. Eye Res.16, 102.
Ruiz, A., et al. 1996. Biochem. Biophys. Res. Commun.226, 467.
Kishnani, N.S., et al. 1995. Matrix Biol.14, 479.
Cottam, D.W. and Rees, R.C. 1993. Intl J. Oncol.2, 861.
Stetler-Stevenson, W. G., et al. 1993. FASEB J.7, 1434.
Woessner, J.F. 1991. FASEB J.5, 2145.
Liotta, L.A. and Stetler-Stevenson, W.G. 1990. in Seminars in Cancer Biology, ed. M. M. Gottesman. Vol. 1(2), 99.
Packaging
Please refer to vial label for lot-specific concentration.
Physical form
In 100 mM sodium phosphate buffer, 0.1% BSA, pH 7.0.
Preparation Note
Following initial thaw, aliquot and freeze (-20°C).
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存储类别
10 - Combustible liquids
wgk
WGK 1
Yasuyuki Shitomi et al.
Molecular biology of the cell, 26(4), 659-673 (2014-12-30)
Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase that binds and transmits signals from various collagens in epithelial cells. However, how DDR1-dependent signaling is regulated has not been understood. Here we report that collagen binding induces ADAM10-dependent ectodomain
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