biological source
mouse
antibody product type
primary antibodies
clone
182-12G5, monoclonal
form
liquid
contains
≤0.1% sodium azide as preservative
species reactivity
human
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles
isotype
IgG1
shipped in
wet ice
storage temp.
−20°C
Quality Level
General description
Purified mouse monoclonal antibody (see application references). Recognizes the ~28 kDa cathepsin K protein.
Recognizes the ~28 kDa cathepsin K protein in human osteoclasts.
Immunogen
a synthetic peptide (SEDAYPYVGQEESC) corresponding to amino acids 182-195 of human cathepsin K
Application
Immunoblotting (5 µg/ml)
Analysis Note
Positive Control
Osteoclasts
Osteoclasts
Other Notes
Inaoka, T., et al. 1995. Biochem. Biophys. Res. Commun.206, 89.
Tezuka, K., et al. 1994. J. Biol. Chem.269, 1106.
Barrett, A.J. and Kirschke, H. 1981. Meth. Enzymol.80, 535.
Tezuka, K., et al. 1994. J. Biol. Chem.269, 1106.
Barrett, A.J. and Kirschke, H. 1981. Meth. Enzymol.80, 535.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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存储类别
10-13 - German Storage Class 10 to 13
法规信息
监管及禁止进口产品
此项目有
Monica Pata et al.
Genesis (New York, N.Y. : 2000), 59(3), e23409-e23409 (2021-01-24)
Mutations in the osteopetrotic transmembrane protein 1 (Ostm1) gene are responsible for the most severe form of autosomal recessive osteopetrosis both in humans and in the gray lethal (gl/gl) mouse. This defect leads to increased bone mass with bone marrow
Stephanie Dauth et al.
BMC neuroscience, 12, 74-74 (2011-07-29)
Cathepsin K is a cysteine peptidase known for its importance in osteoclast-mediated bone resorption. Inhibitors of cathepsin K are in clinical trials for treatment of osteoporosis. However, side effects of first generation inhibitors included altered levels of related cathepsins in
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