生物来源
mouse
质量水平
抗体产品类型
primary antibodies
克隆
182-12G5, monoclonal
表单
liquid
包含
≤0.1% sodium azide as preservative
种属反应性
human
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
avoid repeated freeze/thaw cycles
同位素/亚型
IgG1
运输
wet ice
储存温度
−20°C
一般描述
Purified mouse monoclonal antibody (see application references). Recognizes the ~28 kDa cathepsin K protein.
Recognizes the ~28 kDa cathepsin K protein in human osteoclasts.
免疫原
a synthetic peptide (SEDAYPYVGQEESC) corresponding to amino acids 182-195 of human cathepsin K
应用
Immunoblotting (5 µg/ml)
分析说明
Positive Control
Osteoclasts
Osteoclasts
其他说明
Inaoka, T., et al. 1995. Biochem. Biophys. Res. Commun.206, 89.
Tezuka, K., et al. 1994. J. Biol. Chem.269, 1106.
Barrett, A.J. and Kirschke, H. 1981. Meth. Enzymol.80, 535.
Tezuka, K., et al. 1994. J. Biol. Chem.269, 1106.
Barrett, A.J. and Kirschke, H. 1981. Meth. Enzymol.80, 535.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
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储存分类代码
10-13 - German Storage Class 10 to 13
法规信息
监管及禁止进口产品
此项目有
Monica Pata et al.
Genesis (New York, N.Y. : 2000), 59(3), e23409-e23409 (2021-01-24)
Mutations in the osteopetrotic transmembrane protein 1 (Ostm1) gene are responsible for the most severe form of autosomal recessive osteopetrosis both in humans and in the gray lethal (gl/gl) mouse. This defect leads to increased bone mass with bone marrow
Stephanie Dauth et al.
BMC neuroscience, 12, 74-74 (2011-07-29)
Cathepsin K is a cysteine peptidase known for its importance in osteoclast-mediated bone resorption. Inhibitors of cathepsin K are in clinical trials for treatment of osteoporosis. However, side effects of first generation inhibitors included altered levels of related cathepsins in
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