产品名称
Anti-Integrin α5β1 Antibody, clone HA5, clone HA5, Chemicon®, from mouse
生物来源
mouse
质量水平
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
HA5, monoclonal
种属反应性
pig, human
制造商/商品名称
Chemicon®
技术
flow cytometry: suitable
immunoprecipitation (IP): suitable
同位素/亚型
IgG2bκ
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... ITGA5(3678)
应用
Anti-Integrin α5β1 Antibody, clone HA5 detects level of Integrin α5β1 & has been published & validated for use in FC & IP.
Immunoprecipitation of VLA-5 integrins from lysate of 10E6 cell equivalent requires 2 μg of MAB1999.
Flow cytometry: 10 μg/mL
Does not detect VLA-5 by Western blot.
MAB1999 does not affect VLA-5 mediated cell adhesion to fibronectin.
Optimal working dilutions must be determined by end user.
Flow cytometry: 10 μg/mL
Does not detect VLA-5 by Western blot.
MAB1999 does not affect VLA-5 mediated cell adhesion to fibronectin.
Optimal working dilutions must be determined by end user.
生化/生理作用
Reacts with the fibronectin receptor VLA-5 (alpha-5beta-1) integrin complex.
外形
Format: Purified
Purified immunoglobulin from Protein A chromatography. Liquid in 0.02 M PB pH 7.6, 0.25 M NaCl, 0.1% sodium azide.
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Ingrid Burvenich et al.
Molecular cancer therapeutics, 7(12), 3771-3779 (2008-12-17)
This study identifies and characterizes the antigen recognized by monoclonal antibody (mAb) 14C5. We compared the expression of antigen 14C5 with the expression of eight integrin subunits (alpha1, alpha2, alpha3, alphav, beta1, beta2, beta3, and beta4) and three integrin heterodimers
Qinglei Hang et al.
The Journal of biological chemistry, 290(49), 29345-29360 (2015-10-21)
Integrin α5β1-mediated cell adhesion regulates a multitude of cellular responses, including cell proliferation, survival, and cross-talk between different cellular signaling pathways. Integrin α5β1 is known to convey permissive signals enabling anchorage-dependent receptor tyrosine kinase signaling. However, the effects of integrin
Yuya Sato et al.
The Journal of biological chemistry, 284(18), 11873-11881 (2009-03-12)
Recently we reported that N-glycans on the beta-propeller domain of the integrin alpha5 subunit (S-3,4,5) are essential for alpha5beta1 heterodimerization, expression, and cell adhesion. Herein to further investigate which N-glycosylation site is the most important for the biological function and
Paul Day et al.
International journal of oncology, 39(4), 863-871 (2011-07-02)
Integrins, a family of heterodimeric receptors for cell adhesion to the extracellular matrix (ECM), play key roles in cell migration, cancer progression and metastasis. As transmembrane proteins, integrins are transported in vesicles and delivered to the cell surface by vesicular
Elisabetta Vergani et al.
Oncotarget, 7(4), 4428-4441 (2015-12-20)
In melanoma, the adaptative cell response to BRAF inhibitors includes altered patterns of cytokine production contributing to tumor progression and drug resistance. Among the factors produced by PLX4032-resistant melanoma cell lines, CCL2 was higher compared to the sensitive parental cell
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