产品名称
抗囊性纤维化跨膜电导调节剂抗体，克隆MM13-4, clone MM13-4, Chemicon®, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
MM13-4, monoclonal
species reactivity
human
should not react with
mouse, shark
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CFTR(1080)
Application
使用经验证用于IC、IP & WB的抗囊性纤维化跨膜传导调节蛋白抗体（克隆MM13-4）检测囊性纤维化跨膜传导调节蛋白。
研究子类别
离子通道 & 转运蛋白
离子通道 & 转运蛋白
研究类别
神经科学
神经科学
蛋白质印迹：10 μg/mL，可识别CFTR（150-170kDa）和另外两个52kDa和38kDa的蛋白
免疫沉淀
免疫荧光
注意：在石蜡包埋组织上不起作用。
最佳工作稀释度必须由最终用户进行确定。
免疫沉淀
免疫荧光
注意：在石蜡包埋组织上不起作用。
最佳工作稀释度必须由最终用户进行确定。
Biochem/physiol Actions
人囊性纤维化跨膜传导调节蛋白（CFTR）。识别残基24和35之间的N端表位。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Immunogen
合成肽（RKGYRQRLELSD），对应于人囊性纤维化跨膜传导调节蛋白（CFTR）的残基25-36。
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
形式：纯化
纯化的免疫球蛋白。 液体形式，溶于0.02 M磷酸盐缓冲液、0.25 M NaCl（pH 7.6）和0.1%叠氮化钠中。
Preparation Note
以未稀释等分试样保存于2-8°C下6个月。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Onofrio Laselva et al.
Frontiers in pharmacology, 9, 719-719 (2018-07-20)
The psoralen-related compound, 4,6,4'-trimethylangelicin (TMA) potentiates the cAMP/PKA-dependent activation of WT-CFTR and rescues F508del-CFTR-dependent chloride secretion in both primary and secondary airway cells homozygous for the F508del mutation. We recently demonstrated that TMA, like lumacaftor (VX-809), stabilizes the first membrane-spanning
Yukiko Sato et al.
Scientific reports, 11(1), 23256-23256 (2021-12-03)
There is evidence that the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel is highly expressed at the apical pole of ciliated cells in human bronchial epithelium (HBE), however recent studies have detected little CFTR mRNA in those cells. To
Lianwu Fu et al.
The Biochemical journal, 441(2), 633-643 (2011-10-15)
CFTR (cystic fibrosis transmembrane conductance regulator) is expressed in the apical membrane of epithelial cells. Cell-surface CFTR levels are regulated by endocytosis and recycling. A number of adaptor proteins including AP-2 (μ2 subunit) and Dab2 (Disabled-2) have been proposed to
Chunying Li et al.
The Journal of biological chemistry, 279(23), 24673-24684 (2004-04-03)
Based on electrophysiological measurements, it has been argued that the active form of cystic fibrosis trans-membrane conductance regulator (CFTR) Cl(-) channel is a multimer. It has also been demonstrated that this multimerization is likely due to PDZ domain-interacting partners. Here
Hong Yu Ren et al.
Molecular biology of the cell, 24(19), 3016-3024 (2013-08-09)
Cystic fibrosis (CF) is a fatal genetic disorder associated with defective hydration of lung airways due to the loss of chloride transport through the CF transmembrane conductance regulator protein (CFTR). CFTR contains two membrane-spanning domains (MSDs), two nucleotide-binding domains (NBDs)
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