产品名称
抗囊性纤维化跨膜电导调节剂抗体，克隆MM13-4, clone MM13-4, Chemicon®, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
MM13-4, monoclonal
species reactivity
human
should not react with
mouse, shark
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CFTR(1080)
Application
使用经验证用于IC、IP & WB的抗囊性纤维化跨膜传导调节蛋白抗体（克隆MM13-4）检测囊性纤维化跨膜传导调节蛋白。
研究子类别
离子通道 & 转运蛋白
离子通道 & 转运蛋白
研究类别
神经科学
神经科学
蛋白质印迹：10 μg/mL，可识别CFTR（150-170kDa）和另外两个52kDa和38kDa的蛋白
免疫沉淀
免疫荧光
注意：在石蜡包埋组织上不起作用。
最佳工作稀释度必须由最终用户进行确定。
免疫沉淀
免疫荧光
注意：在石蜡包埋组织上不起作用。
最佳工作稀释度必须由最终用户进行确定。
Biochem/physiol Actions
人囊性纤维化跨膜传导调节蛋白（CFTR）。识别残基24和35之间的N端表位。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Immunogen
合成肽（RKGYRQRLELSD），对应于人囊性纤维化跨膜传导调节蛋白（CFTR）的残基25-36。
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
形式：纯化
纯化的免疫球蛋白。 液体形式，溶于0.02 M磷酸盐缓冲液、0.25 M NaCl（pH 7.6）和0.1%叠氮化钠中。
Preparation Note
以未稀释等分试样保存于2-8°C下6个月。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
未找到合适的产品？
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Lianwu Fu et al.
The Biochemical journal, 441(2), 633-643 (2011-10-15)
CFTR (cystic fibrosis transmembrane conductance regulator) is expressed in the apical membrane of epithelial cells. Cell-surface CFTR levels are regulated by endocytosis and recycling. A number of adaptor proteins including AP-2 (μ2 subunit) and Dab2 (Disabled-2) have been proposed to
Chunying Li et al.
The Journal of biological chemistry, 279(23), 24673-24684 (2004-04-03)
Based on electrophysiological measurements, it has been argued that the active form of cystic fibrosis trans-membrane conductance regulator (CFTR) Cl(-) channel is a multimer. It has also been demonstrated that this multimerization is likely due to PDZ domain-interacting partners. Here
Hong Yu Ren et al.
Molecular biology of the cell, 24(19), 3016-3024 (2013-08-09)
Cystic fibrosis (CF) is a fatal genetic disorder associated with defective hydration of lung airways due to the loss of chloride transport through the CF transmembrane conductance regulator protein (CFTR). CFTR contains two membrane-spanning domains (MSDs), two nucleotide-binding domains (NBDs)
Loïc Drévillon et al.
PloS one, 6(3), e18334-e18334 (2011-04-13)
The CFTR (cystic fibrosis transmembrane conductance regulator) protein is a large polytopic protein whose biogenesis is inefficient. To better understand the regulation of CFTR processing and trafficking, we conducted a genetic screen that identified COMMD1 as a new CFTR partner.
Jie Ting Zhang et al.
Scientific reports, 7(1), 5233-5233 (2017-07-14)
Cystic fibrosis transmembrane conductance regulator (CFTR), known as a cAMP-activated Cl- channel, is widely expressed at the apical membrane of epithelial cells in a wide variety of tissues. Of note, despite the abundant expression of CFTR in mammalian kidney, the
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持