biological source
mouse
antibody form
ascites fluid
antibody product type
primary antibodies
clone
PRK8, monoclonal
species reactivity
human, mouse
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG2b
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... PARK2(5071)
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Immunogen
重组人parkin。
Application
抗Parkin抗体，克隆PRK8是用于IP、WB、IH的抗Parkin抗体。
研究子类别
神经退行性疾病
神经退行性疾病
研究类别
神经科学
神经科学
蛋白质印迹法：该抗体可检测小鼠脑提取物中约50和约44 kDa的条带。在人脑提取物中，抗体与~50和~46 kDa反应。免疫组织化学
免疫细胞化学
免疫沉淀
最佳工作稀释度必须由最终用户确定。
免疫细胞化学
免疫沉淀
最佳工作稀释度必须由最终用户确定。
Biochem/physiol Actions
Parkin。单克隆识别的表位在人Parkin的氨基酸399-465之间。该抗体与parkin基因缺失小鼠提取物中的蛋白质无交叉反应性。
Physical form
腹水液。 液体。不含防腐剂。
Preparation Note
接收后，以未稀释的等分试样在-20°C下保存长达12个月。应避免反复冻/融循环。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Parkin is an E3 ubiquitin-ligase for normal and mutant ataxin-2 and prevents ataxin-2-induced cell death.
Huynh, DP; Nguyen, DT; Pulst-Korenberg, JB; Brice, A; Pulst, SM
Experimental neurology null
Fumika Koyano et al.
Genes to cells : devoted to molecular & cellular mechanisms, 18(8), 672-681 (2013-06-12)
PINK1 and PARKIN are causal genes for hereditary Parkinsonism. Recent studies have shown that PINK1 and Parkin play a pivotal role in the quality control of mitochondria, and dysfunction of either protein likely results in the accumulation of low-quality mitochondria
J Viotti et al.
Oncogene, 33(14), 1764-1775 (2013-05-07)
Gliomas represent the most frequent form of primary brain tumors in adults, the prognosis of which remains extremely poor. Inactivating mutations on the tumor suppressor TP53 were proposed as a key etiological trigger of glioma development. p53 has been recently
Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.
da Costa, CA; Sunyach, C; Giaime, E; West, A; Corti, O; Brice, A; Safe, S; Abou-Sleiman et al.
Nature Cell Biology null
Parkin differently regulates presenilin-1 and presenilin-2 functions by direct control of their promoter transcription.
Duplan, E; Sevalle, J; Viotti, J; Goiran, T; Bauer, C; Renbaum, P; Levy-Lahad, E; Gautier et al.
Journal of Molecular Cell Biology null
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