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Merck
CN

MAB5566

Sigma-Aldrich

Anti-Tubulin α Antibody, detyrosinated

ascites fluid, Chemicon®

别名:

Anti-Anti-B-ALPHA-1, Anti-Anti-LIS3, Anti-Anti-TUBA3

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关于此项目

UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41
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生物来源

mouse

抗体形式

ascites fluid

抗体产品类型

primary antibodies

克隆

monoclonal

种属反应性(根据同源性预测)

mammals

制造商/商品名称

Chemicon®

技术

western blot: suitable

同位素/亚型

IgG2a

NCBI登记号

UniProt登记号

运输

dry ice

靶向翻译后修饰

unmodified

基因信息

human ... TUBA1A(7846)

免疫原

Epitope: detyrosinated
Synthetic peptide GEEEGE.

应用

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Research Category
Neuroscience
Research Sub Category
Neurofilament & Neuron Metabolism

Neuronal & Glial Markers
This Anti-Tubulin Antibody, α, detyrosinated is validated for use in WB for the detection of Tubulin.

生化/生理作用

Alpha tubulin, detyrosinated.

外形

Liquid. Contains no preservative.

制备说明

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

法律信息

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Tubulin posttranslational modifications (PTMs) modulate the dynamic properties of microtubules and their interactions with other proteins. However, the effects of tubulin PTMs were often revealed indirectly through the deletion of modifying enzymes or the overexpression of tubulin mutants. In this
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Translational neurodegeneration, 4, 9-9 (2015-06-02)
In Alzheimer disease (AD), hyperphosphorylation of tau proteins results in microtubule destabilization and cytoskeletal abnormalities. Our prior ultra-morphometric studies documented a clear reduction in microtubules in pyramidal neurons in AD compared to controls, however, this reduction did not coincide with
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Brain : a journal of neurology (2022-02-12)
Microtubules play fundamental roles in the maintenance of neuronal processes and in synaptic function and plasticity. While dynamic microtubules are mainly composed of tyrosinated tubulin, long-lived microtubules contain detyrosinated tubulin, suggesting that the tubulin tyrosination/detyrosination cycle is a key player
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International journal of molecular sciences, 22(11) (2021-07-03)
During aggressive cancer progression, cancer cells adapt to unique microenvironments by withstanding various cellular stresses, including endoplasmic reticulum (ER) stress. However, the mechanism whereby cancer cells overcome the ER stress to survive remains to be elucidated. Herein, we demonstrated that

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