Anti-B-cell lymphoma/leukemia 11B, clone 3A8.2 Antibody

B-cell lymphoma/leukemia 11B, also known as B-cell lymphoma/leukemia 11B (BCL-11B), B-cell CLL/lymphoma 11B, COUP-TF-interacting protein 2, Radiation-induced tumor suppressor gene 1 protein, hRit1, and encoded by the gene name BCL11B/ CTIP2/ RIT1, is a tumor-suppressor protein involved in t-cell lymphomas. B-cell lymphoma/leukemia 11B have been shown to play a role in the p53-signaling pathway. B-cell lymphoma/leukemia 11B may be a key regulator of both differentiation and survival during thymocyte development. B-cell lymphoma/leukemia 11B represses transcription through direct, tfcoup2-independent binding to a gc-rich response element. B-cell lymphoma/leukemia 11B interacts with tfcoup1, sirt1, arp1 and ear2. B-cell lymphoma/leukemia 11B is highly expressed in brain and in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma.

~94 and ~86 kDa observed

GST-tagged recombinant protein corresponding to human B-cell lymphoma/leukemia 11B.

Anti-B-cell lymphoma/leukemia 11B, clone 3A8.2 is an antibody against B-cell lymphoma/leukemia 11B for use in WB, ICC.

Immunocytochemistry Analysis: 20 µg/mL from a representative lot detected B-cell lymphoma/leukemia 11B in Jurkat cells.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Nuclear Receptors

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Evaluated by Western Blotting in Jurkat cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected B-cell lymphoma/leukemia 11B in 10 µg of Jurkat cell lysate.

Concentration: Please refer to lot specific datasheet.

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