Anti-IRF8 Antibody, clone 8C6.2

Interferon regulatory factor 8 (IRF-8) is also known as interferon consensus sequence-binding protein. Interferon regulatory factors (IRFs) comprise a family of transcription factors that function with the Jak/Stat pathway to regulate interferon (IFN) and IFN-inducible gene expression in response to viral infection. IRF-8 specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes at the interferon consensus sequence (ICS). IRF-8 has a negative regulatory function in immune cells, can be induced by IFNG/ IFN-gamma and is involved in CD8+ dendritic cell differentiation. IRF-8 is predominantly expressed in lymphoid tissues. IRF-8 is implicated in MS.

~48 kDa observed

Linear peptide corresponding to human IRF8.

Detect IRF-8 using this mouse monoclonal antibody, Anti-IRF8 Antibody, clone 8C6.2 validated for use in western blotting & IHC.

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

Western Blotting Analysis: 1.0 µg/mL from a representative lot detected IRF8 in 10 µg of human spleen tissue lysate.
Western Blotting Analysis: 1.0 µg/mL from a representative lot detected IRF8 in 10 µg of Jurkat cell lysate.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected IRF8 in human tonsil tissue.

Purified by Ion-Exchange Chromatography

Format: Purified

Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
THP-1 cell lysate

Evaluated by Western Blotting in THP-1 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected IRF8 in 10 µg of THP-1 cell lysate.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.