MABN498
Anti-GABA(A)R BETA 1 Protein Antibody, clone N96/55
clone N96/55, from mouse
别名:
Gamma-aminobutyric acid receptor subunit beta-1, GABA(A) receptor subunit beta-1
biological source
mouse
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
N96/55, monoclonal
species reactivity
mouse, rat
technique(s)
immunohistochemistry: suitable, western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
mouse ... Gabrb1(14400)
General description
GABA(A)R, beta-1 is a subunit of the GABA receptor. GABA receptors belong to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid or GABA is the major inhibitory neurotransmitter in the vertebrate brain. GABA mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. GABA receptors play an important role in transmembrane ion transport, excitability and synaptic transmission.
~55 kDa observed
Immunogen
Fusion protein corresponding to mouse GABA(A)R, BETA 1.
Application
Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected GABA(A)R, BETA 1 Protein in rat olfactory lobe tissue.
Western Blot Analysis: A representative lot detected GABA(A)R, BETA 1 Protein in rat brain membrane tissue lysate.
Immunohistochemistry Analysis: A representative lot detected GABA(A)R, BETA 1 Protein in rat hippocampus tissue.
Western Blot Analysis: A representative lot detected GABA(A)R, BETA 1 Protein in rat brain membrane tissue lysate.
Immunohistochemistry Analysis: A representative lot detected GABA(A)R, BETA 1 Protein in rat hippocampus tissue.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Signaling Neuroscience
Signaling Neuroscience
This GABA(A)R antibody is validated for use in IHC & WB for the detection of the GABA(A)R protein.
Biochem/physiol Actions
Other homologies: Human (95% sequence homology).
This antibody does not cross react with GABA-A-R, Beta 2 Protein or GABA-A-R, Beta 3 Protein.
Physical form
Format: Purified
Protein G Purified
Purified monoclonal mouse IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
Rat hippocampus tissue
Rat hippocampus tissue
Evaluated by Immunohistochemistry in rat hippocampus tissue.
Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected GABA(A)R, BETA 1 Protein in rat hippocampus tissue.
Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected GABA(A)R, BETA 1 Protein in rat hippocampus tissue.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品？
试试我们的产品选型工具.
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Jingjing Duan et al.
Frontiers in cellular neuroscience, 13, 217-217 (2019-06-25)
In the adult brain GABAA receptors (GABAARs) mediate the majority of synaptic inhibition that provides inhibitory balance to excitatory drive and controls neuronal output. In the immature brain GABAAR signaling is critical for neuronal development. However, the cell-autonomous role of
Jonathon Smith et al.
British journal of pharmacology, 180(13), 1710-1729 (2023-01-14)
Neonatal seizures represent a clinical emergency. However, current anti-seizure medications fail to resolve seizures in ~50% of infants. The P2X7 receptor (P2X7R) is an important driver of inflammation, and evidence suggests that P2X7R contributes to seizures and epilepsy in adults.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持