Anti-Pan-GRK Antibody, clone N145/20

G protein-coupled receptor kinases (GRK) are serine/threonine kinases that phosphorylate a variety of G-protein-coupled receptors (GPCRs), specifically activated forms, including adrenergic receptors, muscarinic acetylcholine receptors, dopamine receptors and opioid receptors. GRK receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation.

~ 68 kDa observed

Epitope: C-terminus

Recombinant protein corresponding to the C-terminus of mouse Pan-GRK.

Anti-Pan-GRK Antibody, clone N145/20 Cat. No. MABN615 is a highly specific mouse monoclonal antibody & that targets GRK & has been tested in western blotting.

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

This antibody recognizes the C-terminus of GRK. This antibody cross reacts with GRK6 (Prof. J. Trimmer, University of California, Davis.).

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
Mouse liver tissue lysate

Evaluated by Western Blotting in mouse liver tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected Pan-GRK in 10 µg of mouse liver tissue lysate.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.