Anti-Nalcn Antibody, clone N185/7

Sodium leak channel non-selective protein (NALCN) is also called Four domain-type voltage-gated ion channel alpha-1 subunit and Voltage gated channel-like protein 1 (Vgcnl1). NALCN is a voltage-independent, cation-nonselective channel which transports sodium, potassium and calcium ions. NALCN maintains the background sodium ion leak current in neurons, controls neuronal excitability and is essential for normal respiratory rhythm and neonatal survival. NALCN is activated by substance P or neurotensin, and is mainly expressed in the brain or to a lesser extent, heart and pancreas.

~ 200 kDa observed

Epitope: C terminal cytoplasmic domain

Recombinant protein corresponding to the C terminal cytoplasmic domain of rat Nalcn.

Anti-Nalcn Antibody, clone N185/7 is a highly specific mouse monoclonal antibody & that targets Sodium leak channel non-selective protein & has been tested in western blotting.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Nalcn in rat brain tissue.

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

This antibody recognizes the C terminal cytoplasmic domain of Nalcn.

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Evaluated by Western Blotting in human hippocampus membrane tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Nalcn in 10 µg of human hippocampus membrane tissue lysate.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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