biological source
mouse
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
N195A/16, monoclonal
species reactivity
rat, human
species reactivity (predicted by homology)
mouse (based on 100% sequence homology)
technique(s)
immunohistochemistry: suitable, western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... QKI(9444)
General description
45 kDa calculated
QKI (Quaking) is an RNA-binding protein that plays a central role in myelinization. QKI acts by regulating pre-mRNA splicing, mRNA export, mRNA stability, and protein translation. It is regulated by alternative splicing. There are at least 6 known isoforms, and QKI-5 refers to isoforms 1, which is the ′canonical′ sequence, consisting of 341 amino acids.
Immunogen
Linear peptide corresponding to human QKI-5.
Application
Detect QKI using this mouse monoclonal antibody, Anti-QKI-5 Antibody, clone N195A/16 validated for use in IHC & western blotting.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected QKI-5 in human cerebellum and thalamus tissues, and in rat hippocampus tissue.
Western Blotting Analysis: A representative lot detected QKI-5 in COS cell lysates transiently transfected with Flag-tagged QKI-5 (Prof. J. Trimmer, University of California, Davis.).
Western Blotting Analysis: A representative lot detected QKI-5 in COS cell lysates transiently transfected with Flag-tagged QKI-5 (Prof. J. Trimmer, University of California, Davis.).
Biochem/physiol Actions
This antibody does not cross react with QKI-6, QKI-7, and QKI-7b. This antibody may cross react with other STAR proteins containing similar nuclear localization signals (Prof. J. Trimmer, Univerisity of California, Davis.).
Physical form
Format: Purified
Analysis Note
Evaluated by Immunohistochemistry in rat cerebellum tissue.
Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected QKI-5 in rat cerebellum tissue.
Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected QKI-5 in rat cerebellum tissue.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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