Anti-hCG beta 3, clone P3W80

Anti-hCG beta 3, clone P3W80, Cat. No. MABS2062, is a mouse monoclonal antibody that detects Choriogonadotropin subunit beta 3 and has been tested for use in ELISA, Flow Cytometry, and Immunohistochemistry (Paraffin).

ELISA Flow Cytometry Immunohistochemistry (Paraffin)

Flow Cytometry Analysis: A representative lot detected hCG beta 3 in Flow Cytometry applications (Arora, G., et.l al. (2016). Ann Nucl Med. 30(5):334-45).

ELISA Analysis: A representative lot detected hCG beta 3 in ELISA applications (Arora, G., et.l al. (2016). Ann Nucl Med. 30(5):334-45).

Clone P3W80 is a mouse monoclonal antibody that detects human Choriogonadotropin subunit beta 3.

Purified human chorionic gonadotropin, beta subunit.

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Purified mouse monoclonal antibody IgG1 in PBS without azide.

Choriogonadotropin subunit beta 3 (UniProt: P0DN86; also known as Choriogonadotropin subunit beta, CG-beta, Chorionic gonadotropin chain beta, hCG) is encoded by the CGB3 (also known as CGB, CGB5, CBG8) gene (Gene ID: 1082, 93659, 94115) in human. hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta that are non-covalently associated. The alpha subunit is shown to be identical to that found in the pituitary gonadotropin hormones (LH, FSH and TSH). However, the beta subunits are distinct in each of the hormones and confer receptor and biological specificity. It displays high expression in placenta throughout pregnancy with peak during the first trimester. hCG beta 3 is synthesized with signal peptide (aa 1-20), which is cleaved off to generate the mature form. hCG plays an essential role in pregnancy and maternal adaptation. It stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. Two isoforms of hCG beta 3 have been described that are produced by alternative splicing.

Evaluated by Immunohistochemistry (Paraffin) in human placenta tissue sections.

Immunohistochemistry (Paraffin) Analysis: A 1:250 dilution of this antibody detected hCG beta 3 in human placenta tissue sections.

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