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About This Item

UNSPSC代码:
12352203
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生物来源

mouse

质量水平

偶联物

unconjugated

抗体形式

purified antibody

抗体产品类型

primary antibodies

克隆

AD105, monoclonal

分子量

calculated mol wt 26.41 kDa
observed mol wt ~N/A kDa

纯化方式

using protein G

种属反应性

human

包装

antibody small pack of 100

技术

ELISA: suitable

同位素/亚型

IgG1κ

表位序列

Unknown

Protein ID登记号

UniProt登记号

储存温度

2-8°C

靶向翻译后修饰

unmodified

基因信息

human ... ADIPOQ(9370)

特异性

Clone AD105 is a mouse recombinant monoclonal antibody that detects Adiponectin. Suitable for ELISA application paired with Anti-Adiponectin, clone AD72 (MABS2439).

免疫原

hFc-tagged, full length, human recombinant Adiponectin.

应用

Quality Control Testing

Evaluated by ELISA with hFc-tagged, full length, human recombinant Adiponectin.


Enzyme Immunoassay (ELISA): Various dilutions from a representative lot of this antibody detected recombinant human Adiponectin protein in ELISA application.

目标描述

Adiponectin (UniProt: Q15848; also known as 30 kDa adipocyte complement-related protein, Adipocyte complement-related 30 kDa protein (ACRP30), Adipocyte, C1q and collagen domain-containing protein, Adipose most abundant gene transcript 1 protein, apM-1, Gelatin-binding protein) is encoded by the ADIPOQ (also known as ACDC, ACRP30, APM1, GBP28) gene (Gene ID: 9370) in human. Adiponectin is a homomultimeric secreted glycoprotein, characterized by a collagen-like domain (aa 42-107) and a globular, C1q domain (aa 108-244). It exists in several oligomeric forms, including trimers (low-molecular-weight (LMW)), hexamers, and 12 to 18-mers (high-molecular-weight (HMW)) complexes, with the HMW form being the most biologically active. Adiponectin enhances insulin sensitivity, regulate glucose metabolism, and promote fatty acid oxidation. It activates various signaling pathways, notably the AMP-activated protein kinase (AMPK) pathway, leading to improved metabolic health. Additionally, adiponectin has anti-inflammatory effects and plays a role in cardiovascular health. Adiponectin is expressed in adipose tissue and secreted into the bloodstream. Low levels of adiponectin are linked to obesity, type 2 diabetes, and cardiovascular diseases. Its anti-inflammatory properties suggest a protective role against atherosclerosis and other inflammatory conditions.



外形

Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

重悬

1 mg/mL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.

储存及稳定性

Recommended storage: +2°C to +8°C.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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